Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Internal Medicine, School of Medicine, Shahid Mostafa Khomaeini Hospital, Ilam University of Medical Sciences, Ilam, Iran.
Infect Disord Drug Targets. 2022;22(1):e210921196697. doi: 10.2174/1871526521666210921121423.
Previous studies suggested an association between Chlamydia pneumoniae and Mycoplasma pneumonia with atherosclerosis, separately. Until now, according to inconsistent information, the relationship between C.pneumoniae and M.pneumoniae with atherosclerosis is controversial.
The aim of this study is to investigate the association between C.pneumoniae and M.pneumoniae as two separate risk factors with atherosclerosis through systematic review and metaanalysis study.
We searched databases, such as Pubmed, SID, Magiran, Google scholar and Iranmedex, using the following keywords in English and Persian language: C. pneumoniae, M. pneumoniae, and atherosclerosis. Data were analyzed with meta-analysis and a random effect model. Also, in this study, heterogeneity of articles was estimated by using the I2 index. Finally, the data were analyzed with STAT (version 11.2).
Among thirty-eight articles for C. pneumoniae and five articles for M. pneumoniae individually reviewed that included 2980 samples for M. pneumoniae and 23298 samples for C. pneumoniae, the result demonstrated that the association between M. pneumoniae and C. pneumoniae with atherosclerosis is significant with OR (odds ratio) = 1.58 (95% Confidence Interval (CI): 1.00 to 2.50), OR (odds ratio) = 2.25 (95% Confidence Interval (CI): 1.91 to 2.64), respectively.
This systematic review study provides strong evidence for the role of persistent bacterial infections, such as M. pneumoniae and C. pneumoniae, in potential atherosclerosis. Thus, a novel way should be employed for the complete management of bacterial infection.
先前的研究表明，肺炎衣原体和肺炎支原体分别与动脉粥样硬化有关。到目前为止，根据不一致的信息，肺炎衣原体和肺炎支原体与动脉粥样硬化之间的关系仍存在争议。
本研究旨在通过系统评价和荟萃分析研究，调查肺炎衣原体和肺炎支原体作为两个独立的危险因素与动脉粥样硬化之间的关系。
我们使用英文和波斯语关键词在数据库（如 Pubmed、SID、Magiran、Google Scholar 和 Iranmedex）中进行搜索，关键词为：肺炎衣原体、肺炎支原体和动脉粥样硬化。使用荟萃分析和随机效应模型对数据进行分析。此外，在本研究中，使用 I2 指数来估计文章的异质性。最后，使用 STAT（版本 11.2）对数据进行分析。
单独对肺炎衣原体的 38 篇文章和肺炎支原体的 5 篇文章进行了审查，共包括 2980 个肺炎支原体样本和 23298 个肺炎衣原体样本。结果表明，肺炎支原体和肺炎衣原体与动脉粥样硬化之间存在显著关联，OR（比值比）分别为 1.58（95%置信区间（CI）：1.00 至 2.50）和 2.25（95%CI：1.91 至 2.64）。
本系统评价研究为持续性细菌感染（如肺炎支原体和肺炎衣原体）在潜在动脉粥样硬化中的作用提供了有力证据。因此，应该采用新的方法来全面管理细菌感染。
