疟原虫在按蚊中的发育：资源共享的故事。
Plasmodium development in Anopheles: a tale of shared resources.
机构信息
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Trends Parasitol. 2022 Feb;38(2):124-135. doi: 10.1016/j.pt.2021.08.009. Epub 2021 Sep 18.
Abstract
Interactions between the Anopheles mosquito vector and Plasmodium parasites shape how malaria is transmitted in endemic regions. The long association of these two organisms has led to evolutionary processes that minimize fitness costs of infection and benefit both players through shared nutrient resources, parasite immune suppression, and mosquito tolerance to infection. In this review we explore recent data describing how Plasmodium falciparum, the deadliest malaria parasite, associates with one of its most important natural mosquito hosts, Anopheles gambiae, and we discuss the implications of these findings for parasite transmission and vector control strategies currently in development.
摘要
疟蚊媒介与疟原虫寄生虫之间的相互作用决定了疟疾在流行地区的传播方式。这两种生物的长期共生关系导致了进化过程，使感染的适应成本最小化，并通过共享营养资源、寄生虫免疫抑制和蚊子对感染的耐受使两者都受益。在这篇综述中，我们探讨了最近的数据，描述了最致命的疟原虫寄生虫疟原虫如何与它最重要的天然蚊子宿主之一冈比亚按蚊相关联，我们还讨论了这些发现对寄生虫传播和目前正在开发的媒介控制策略的意义。
相似文献
1
Plasmodium development in Anopheles: a tale of shared resources.疟原虫在按蚊中的发育：资源共享的故事。
Trends Parasitol. 2022 Feb;38(2):124-135. doi: 10.1016/j.pt.2021.08.009. Epub 2021 Sep 18.
2
Additional Feeding Reveals Differences in Immune Recognition and Growth of Parasites in the Mosquito Host.额外喂养揭示了蚊子宿主中寄生虫的免疫识别和生长的差异。
mSphere. 2021 Mar 31;6(2):e00136-21. doi: 10.1128/mSphere.00136-21.
3
Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles.甾体激素功能控制按蚊中非竞争型疟原虫发育。
Cell. 2019 Apr 4;177(2):315-325.e14. doi: 10.1016/j.cell.2019.02.036. Epub 2019 Mar 28.
4
The Rare, the Best: Spread of Antimalarial-Resistant Plasmodium falciparum Parasites by Mosquito Vectors.罕见而又致命：疟原虫抗药性寄生虫通过蚊子媒介的传播。
Microbiol Spectr. 2021 Oct 31;9(2):e0085221. doi: 10.1128/Spectrum.00852-21. Epub 2021 Oct 20.
5
A mating-induced reproductive gene promotes Anopheles tolerance to Plasmodium falciparum infection.交配诱导的生殖基因促进了按蚊对疟原虫感染的耐受。
PLoS Pathog. 2020 Dec 21;16(12):e1008908. doi: 10.1371/journal.ppat.1008908. eCollection 2020 Dec.
6
Composition of Anopheles mosquitoes, their blood-meal hosts, and Plasmodium falciparum infection rates in three islands with disparate bed net coverage in Lake Victoria, Kenya.肯尼亚维多利亚湖三个蚊帐覆盖率不同的岛屿上按蚊的组成、其血餐宿主及恶性疟原虫感染率
Malar J. 2017 Sep 8;16(1):360. doi: 10.1186/s12936-017-2015-5.
7
Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum.生物碱瑞香宁对冈比亚按蚊和库蚊传播疟原虫能力的对比影响。
Parasit Vectors. 2021 Sep 15;14(1):479. doi: 10.1186/s13071-021-04992-z.
8
Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for human-to-mosquito Plasmodium falciparum transmission.对疟蚊血餐的基因分型显示出非随机的人类宿主选择：对疟原虫向蚊子传播的影响。
Malar J. 2023 Apr 7;22(1):115. doi: 10.1186/s12936-023-04541-2.
9
PIMMS43 is required for malaria parasite immune evasion and sporogonic development in the mosquito vector.PIMMS43 对于疟原虫在蚊媒中的免疫逃避和孢子生殖发育是必需的。
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7363-7373. doi: 10.1073/pnas.1919709117. Epub 2020 Mar 12.
10
Development of circulating isolates of Plasmodium falciparum is accelerated in Anopheles vectors with reduced reproductive output.疟原虫循环分离株在繁殖力降低的按蚊媒介中发育加速。
PLoS Negl Trop Dis. 2024 Jan 11;18(1):e0011890. doi: 10.1371/journal.pntd.0011890. eCollection 2024 Jan.
引用本文的文献
1
OocystMeter, a machine-learning algorithm to count and measure oocysts, reveals clustering patterns in the midgut.卵囊计数器是一种用于计数和测量卵囊的机器学习算法，它揭示了中肠中的聚集模式。
bioRxiv. 2025 Jun 29:2025.06.28.662088. doi: 10.1101/2025.06.28.662088.
2
Biting time of day in malaria mosquitoes is modulated by nutritional status.疟蚊一天中的叮咬时间受营养状况调节。
bioRxiv. 2025 May 1:2025.04.28.650966. doi: 10.1101/2025.04.28.650966.
3
Advances in the dissection of Anopheles-Plasmodium interactions.按蚊-疟原虫相互作用剖析的进展
PLoS Pathog. 2025 Mar 31;21(3):e1012965. doi: 10.1371/journal.ppat.1012965. eCollection 2025 Mar.
4
Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity.冈比亚按蚊的吞噬血细胞通过调节中肠上皮完整性来促进恶性疟原虫感染。
Nat Commun. 2025 Feb 8;16(1):1465. doi: 10.1038/s41467-025-56313-y.
5
Coevolutionary Analysis of the Pfs47-P47Rec Complex: A Bioinformatics Approach.疟原虫Pfs47-P47Rec复合体的共进化分析：一种生物信息学方法。
Bioinform Biol Insights. 2024 Oct 8;18:11779322241284223. doi: 10.1177/11779322241284223. eCollection 2024.
6
Additional blood meals increase sporozoite infection in Anopheles mosquitoes but not Plasmodium falciparum genetic diversity.额外的血液摄入会增加疟原蚊感染子孢子的感染率，但不会增加疟原虫的遗传多样性。
Sci Rep. 2024 Jul 29;14(1):17467. doi: 10.1038/s41598-024-67990-y.
7
Transmission-Blocking Strategies for Malaria Eradication: Recent Advances in Small-Molecule Drug Development.用于疟疾根除的传播阻断策略：小分子药物开发的最新进展
Pharmaceuticals (Basel). 2024 Jul 19;17(7):962. doi: 10.3390/ph17070962.
8
Characterization of the Tissue and Strain-Specific Microbiota of Giles (Diptera: Culicidae).吉尔斯按蚊（双翅目：蚊科）组织和菌株特异性微生物群的特征分析
Trop Med Infect Dis. 2024 Apr 13;9(4):84. doi: 10.3390/tropicalmed9040084.
9
mosGILT controls innate immunity and germ cell development in Anopheles gambiae.mosGILT 控制冈比亚按蚊的先天免疫和生殖细胞发育。
BMC Genomics. 2024 Jan 9;25(1):42. doi: 10.1186/s12864-023-09887-0.
10
Mosquito ageing modulates the development, virulence and transmission potential of pathogens.蚊子衰老调节病原体的发育、毒力和传播潜力。
Proc Biol Sci. 2024 Jan 10;291(2014):20232097. doi: 10.1098/rspb.2023.2097. Epub 2024 Jan 3.
本文引用的文献
1
A single-cell atlas of Plasmodium falciparum transmission through the mosquito.疟原虫通过蚊子传播的单细胞图谱
Nat Commun. 2021 May 27;12(1):3196. doi: 10.1038/s41467-021-23434-z.
2
Additional Feeding Reveals Differences in Immune Recognition and Growth of Parasites in the Mosquito Host.额外喂养揭示了蚊子宿主中寄生虫的免疫识别和生长的差异。
mSphere. 2021 Mar 31;6(2):e00136-21. doi: 10.1128/mSphere.00136-21.
3
Transcriptional heterogeneity and tightly regulated changes in gene expression during sporozoite development.在疟原虫孢子形成期，转录组异质性和基因表达的严格调控变化。
Proc Natl Acad Sci U S A. 2021 Mar 9;118(10). doi: 10.1073/pnas.2023438118.
4
Single-cell RNA sequencing reveals developmental heterogeneity among Plasmodium berghei sporozoites.单细胞 RNA 测序揭示疟原虫孢子虫发育的异质性。
Sci Rep. 2021 Feb 22;11(1):4127. doi: 10.1038/s41598-021-82914-w.
5
Fluorescent tagging of Plasmodium circumsporozoite protein allows imaging of sporozoite formation but blocks egress from oocysts.疟原虫环子孢子蛋白的荧光标记可实现子孢子形成的成像，但会阻止其从卵囊中逸出。
Cell Microbiol. 2021 May;23(5):e13321. doi: 10.1111/cmi.13321. Epub 2021 Mar 15.
6
Plasmodium oocysts respond with dormancy to crowding and nutritional stress.疟原虫卵囊对拥挤和营养胁迫做出休眠反应。
Sci Rep. 2021 Feb 4;11(1):3090. doi: 10.1038/s41598-021-81574-0.
7
Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential.蚊子多次吸血会缩短疟原虫潜伏期并增加疟疾传播的潜力。
PLoS Pathog. 2020 Dec 31;16(12):e1009131. doi: 10.1371/journal.ppat.1009131. eCollection 2020 Dec.
8
A mating-induced reproductive gene promotes Anopheles tolerance to Plasmodium falciparum infection.交配诱导的生殖基因促进了按蚊对疟原虫感染的耐受。
PLoS Pathog. 2020 Dec 21;16(12):e1008908. doi: 10.1371/journal.ppat.1008908. eCollection 2020 Dec.
9
Prostaglandins regulate humoral immune responses in Aedes aegypti.前列腺素调节埃及伊蚊的体液免疫反应。
PLoS Negl Trop Dis. 2020 Oct 23;14(10):e0008706. doi: 10.1371/journal.pntd.0008706. eCollection 2020 Oct.
10
PIMMS43 is required for malaria parasite immune evasion and sporogonic development in the mosquito vector.PIMMS43 对于疟原虫在蚊媒中的免疫逃避和孢子生殖发育是必需的。
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7363-7373. doi: 10.1073/pnas.1919709117. Epub 2020 Mar 12.
Zotero 插件