澳大利亚癌症治疗临床实践指南依从性及影响因素的系统评价方案

Adherence to clinical practice guidelines (CPGs) for the treatment of cancers in Australia and the factors associated with adherence: a systematic review protocol.

机构信息

Australian Institute of Health Innovation, Macquarie University, Sydney, New South Wales, Australia

Australian Institute of Health Innovation, Macquarie University, Sydney, New South Wales, Australia.

出版信息

BMJ Open. 2021 Sep 21;11(9):e050912. doi: 10.1136/bmjopen-2021-050912.

DOI:10.1136/bmjopen-2021-050912

PMID:34548359

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8458325/

Abstract

INTRODUCTION

Clinical practice guidelines (CPGs) synthesise the latest evidence to support clinical and patient decision-making. CPG adherent care is associated with improved patient survival outcomes; however, adherence rates are low across some cancer streams in Australia. Greater understanding of specific barriers to cancer treatment CPG adherence is warranted to inform future implementation strategies.This paper presents the protocol for a systematic review that aims to determine cancer treatment CPG adherence rates in Australia across a variety of common cancers, and to identify any factors associated with adherence to those CPGs, as well as any associations between CPG adherence and patient outcomes.

METHODS AND ANALYSIS

Five databases will be searched, Ovid Medline, PsychInfo, Embase, Scopus and Web of Science, for eligible studies evaluating adherence rates to cancer treatment CPGs in Australia. A team of reviewers will screen the abstracts in pairs according to predetermined inclusion criteria and then review the full text of eligible studies. All included studies will be assessed for quality and risk of bias. Data will be extracted using a predefined data extraction template. The frequency or rate of adherence to CPGs, factors associated with adherence to those CPGs and any reported patient outcome rates (eg, relative risk ratios or 5-year survival rates) associated with adherence to CPGs will be described. If applicable, a pooled estimate of the rate of adherence will be calculated by conducting a random-effects meta-analysis. The systematic review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

ETHICS AND DISSEMINATION

Ethics approval will not be required, as this review will present anonymised data from other published studies. Results from this study will form part of a doctoral dissertation (MB), will be published in a journal, presented at conferences, and other academic presentations.

PROSPERO REGISTRATION NUMBER

CRD42020222962.

摘要

简介

临床实践指南（CPGs）综合了最新的证据，以支持临床和患者决策。CPG 遵循的护理与改善患者生存结果相关；然而，在澳大利亚的一些癌症领域，CPG 的遵循率较低。更深入地了解癌症治疗 CPG 遵循的具体障碍是必要的，以告知未来的实施策略。本文介绍了一项系统评价的方案，旨在确定澳大利亚各种常见癌症的癌症治疗 CPG 遵循率，并确定与 CPG 遵循相关的任何因素，以及 CPG 遵循与患者结果之间的任何关联。

方法和分析

将在五个数据库中搜索符合条件的研究，即 Ovid Medline、PsychInfo、Embase、Scopus 和 Web of Science，以评估澳大利亚癌症治疗 CPG 遵循率。一个审查团队将根据预定的纳入标准成对筛选摘要，然后审查符合条件的研究的全文。所有纳入的研究将进行质量和偏倚风险评估。使用预定义的数据提取模板提取数据。将描述 CPG 遵循的频率或速率、与 CPG 遵循相关的因素以及与 CPG 遵循相关的任何报告的患者结果率（例如，相对风险比或 5 年生存率）。如果适用，将通过进行随机效应荟萃分析计算 CPG 遵循率的合并估计值。系统评价将遵循系统评价和荟萃分析的首选报告项目指南。