Hacettepe University Faculty of Medicine, Intensive Care Unit, Internal Medicine Department - Ankara, Turkey.
Samsun Ondokuz Mayıs University Faculty of Medicine, Internal Medicine-Rheumotology Department - Samsun, Turkey.
Rev Assoc Med Bras (1992). 2021 Jun;67(5):718-723. doi: 10.1590/1806-9282.20210056.
In this study, we aimed to determine fibroblast growth factor 23, soluble alpha klotho, osteocalcin, indoxyl sulphate, sclerostin, Procollagen 1 N Terminal Propeptide, and beta-CrossLaps levels in hemodialysis and peritoneal dialysis patients, and to compare the levels of these markers among hemodialysis and peritoneal dialysis patients, as well as healthy individuals.
The study included 30 hemodialysis and 23 peritoneal dialysis patients who were followed-up for at least six months at the Sakarya University Hospital, besides 30 healthy volunteers.
The participants were divided into three groups with similar characteristics in terms of age, gender and body mass index. Fibroblast growth factor 23, soluble alpha klotho, indoxyl sulphate, beta-CrossLaps, and Procollagen 1 N Terminal Propeptide levels were significantly higher in patients of both the hemodialysis and peritoneal dialysis groups than in the healthy volunteers' group. There was no difference in levels of these molecules between hemodialysis and peritoneal dialysis groups.
Fibroblast growth factor 23, sclerostin, indoxyl sulphate, beta-CrossLaps, and Paclitaxel-induced neuropathic pain levels were higher in patients of both groups as inflammatory markers. In our study, we found higher soluble alpha klotho levels in patients of both groups than in the healthy volunteers' group, suggesting that blood soluble alpha klotho levels may not correlate with renal klotho levels.
本研究旨在测定血液透析和腹膜透析患者成纤维细胞生长因子 23、可溶性 klotho 、骨钙素、吲哚硫酸酯、硬化蛋白、前胶原 1 N 端前肽和β-CrossLaps 的水平，并比较这些标志物在血液透析和腹膜透析患者与健康个体中的水平。
该研究纳入了在萨卡里亚大学医院接受至少 6 个月随访的 30 例血液透析患者和 23 例腹膜透析患者，以及 30 名健康志愿者。
参与者根据年龄、性别和体重指数分为三组，具有相似的特征。成纤维细胞生长因子 23、可溶性 klotho 、吲哚硫酸酯、β-CrossLaps 和前胶原 1 N 端前肽水平在血液透析和腹膜透析组患者中均显著高于健康志愿者组。两组患者之间这些分子的水平没有差异。
成纤维细胞生长因子 23、硬化蛋白、吲哚硫酸酯、β-CrossLaps 和紫杉醇诱导的神经病理性疼痛水平在两组患者中均作为炎症标志物升高。在我们的研究中，我们发现两组患者的可溶性 klotho 水平均高于健康志愿者组，提示血液可溶性 klotho 水平可能与肾脏 klotho 水平无关。
