Universidade Federal de Pernambuco, Department of Internal Medicine, Recife/PE, Brazil.
Clinics (Sao Paulo). 2012;67(2):131-4. doi: 10.6061/clinics/2012(02)07.
The present study was designed to analyze the serum levels of aspartate and alanine aminotransferases, gamma-glutamyl transferase, and the hematocrit in patients with chronic kidney disease who were undergoing peritoneal dialysis or hemodialysis.
Twenty patients on peritoneal dialysis and 40 on hemodialysis were assessed, and the patients were matched according to the length of time that they had been on dialysis. Blood samples were collected (both before and after the session for those on hemodialysis) to measure the enzymes and the hematocrit.
In the samples from the patients who were undergoing peritoneal dialysis, the aspartate and alanine aminotransferase levels were slightly higher compared with the samples collected from the patients before the hemodialysis session and slightly lower compared with the samples collected after the hemodialysis session. The levels of gamma-glutamyl transferase in the hemodialysis patients were slightly higher than the levels in the patients who were undergoing peritoneal dialysis. In addition, the levels of aminotransferases and gamma-glutamyl transferase that were collected before the hemodialysis session were significantly lower than the values collected after the session. The hematocrit levels were significantly lower in the patients who were on peritoneal dialysis compared with the patients on hemodialysis (both before and after the hemodialysis session), and the levels were also significantly lower before hemodialysis compared with after hemodialysis.
The aminotransferase levels in the patients who were undergoing peritoneal dialysis were slightly higher compared with the samples collected before the hemodialysis session, whereas the aminotransferase levels were slightly lower compared with the samples collected after the session. The hematocrits and the aminotransferase and gamma-glutamyl transferase levels of the samples collected after the hemodialysis session were significantly higher than the samples collected before the session. Taken together, the present data suggest that hemodilution could alter the serum levels of liver enzymes.
本研究旨在分析接受腹膜透析或血液透析的慢性肾脏病患者的血清天门冬氨酸和丙氨酸氨基转移酶、γ-谷氨酰转移酶和红细胞压积水平。
评估了 20 名腹膜透析患者和 40 名血液透析患者，并根据透析时间的长短对患者进行匹配。采集血样（血液透析患者采集透析前后的血样）以测量酶和红细胞压积。
腹膜透析患者的天门冬氨酸和丙氨酸氨基转移酶水平略高于血液透析前的样本，略低于血液透析后的样本。血液透析患者的γ-谷氨酰转移酶水平略高于腹膜透析患者。此外，血液透析前采集的氨基转移酶和γ-谷氨酰转移酶水平明显低于血液透析后采集的水平。与血液透析患者相比，腹膜透析患者的红细胞压积水平明显较低（血液透析前后），血液透析前的水平也明显低于血液透析后的水平。
腹膜透析患者的氨基转移酶水平略高于血液透析前的样本，而略低于血液透析后的样本。血液透析后采集的样本的红细胞压积以及氨基转移酶和γ-谷氨酰转移酶水平明显高于血液透析前采集的样本。综上所述，目前的数据表明，血液稀释可能会改变血清肝酶水平。
