Laboratory MIVEGEC, University of Montpellier, CNRS, IRD, 900 rue Jean François Breton, 34090 Montpellier, France.
CREES, Centre de Recherches en Écologie et Évolution de la Santé, Montpellier, France.
FEMS Microbiol Rev. 2022 Feb 9;46(1). doi: 10.1093/femsre/fuab047.
Malaria is considered one of the most important scourges that humanity has faced during its history, being responsible every year for numerous deaths worldwide. The disease is caused by protozoan parasites, among which two species are responsible of the majority of the burden, Plasmodium falciparum and Plasmodium vivax. For these two parasite species, the questions of their origin (how and when they appeared in humans), of their spread throughout the world, as well as how they have adapted to humans have long been of interest to the scientific community. In this paper we review the existing body of knowledge, including current research dealing with these questions, focusing particularly on genetic and genomic analyses of these parasites and comparison with related Plasmodium species infecting other species of host (such as non-human primates).
疟疾被认为是人类历史上所面临的最重要的灾难之一，每年在全球范围内导致大量死亡。该疾病是由原生动物寄生虫引起的，其中两种寄生虫是造成大部分负担的原因，即恶性疟原虫和间日疟原虫。对于这两种寄生虫，它们的起源问题（它们是如何以及何时出现在人类身上的）、在全球范围内的传播，以及它们是如何适应人类的，一直以来都是科学界关注的焦点。在本文中，我们回顾了现有的知识体系，包括当前针对这些问题的研究，特别关注这些寄生虫的遗传和基因组分析，并与感染其他宿主（如非人类灵长类动物）的相关疟原虫物种进行比较。
