Boundenga Larson, Sima-Biyang Yann Vital, Longo-Pendy Neil Michel, Bignoumba Michelle, Mbou-Boutambe Clark, Moukagni-Mussadji Clauve Jauvert, Wora Dorothé Marielle, Kassa-Kassa Fabrice, Onanga Richard, Bisseye Cyrille, Ntoumi Francine, Adegnika Ayola Akim, Lekana-Douki Jean-Bernard
Interdisciplinary Centre of Medical Research of Franceville (CIRMF), Franceville, Gabon.
Department of Anthropology, University of Durham, Durham, UK.
Sci Rep. 2024 Dec 30;14(1):31977. doi: 10.1038/s41598-024-83487-0.
Malaria is a significant public health challenge in Gabon, with high prevalence rates in rural and semi-urban areas. This study investigated Plasmodium infection prevalence among outpatients at a medical laboratory in Franceville, Gabon, in 2020. Data from 500 patients were analyzed, revealing an overall infection rate of 33.2% and the presence of four Plasmodium species: P. falciparum, P. malariae, P. ovale, and possibly P. vivax for the first time in Gabon. Co-infections were common, with P. falciparum and P. ovale spp. being the most prevalent at 23.5%. Asymptomatic infections accounted for 81.3% of cases, while symptomatic infections were 18.7%. P. falciparum was associated with symptomatic cases, while non-falciparum species were linked to asymptomatic infections. The findings suggest Franceville has perennial malaria transmission, highlighting the role of Plasmodium species diversity in disease severity and clinical presentation, including the first report of P. vivax infection in the Gabonese population.
疟疾是加蓬面临的一项重大公共卫生挑战，在农村和半城市地区流行率很高。本研究调查了2020年加蓬弗朗斯维尔一家医学实验室门诊患者中的疟原虫感染率。对500名患者的数据进行了分析，结果显示总体感染率为33.2%，并发现了四种疟原虫：恶性疟原虫、三日疟原虫、卵形疟原虫，加蓬首次可能出现间日疟原虫。混合感染很常见，恶性疟原虫和卵形疟原虫属最为普遍，占23.5%。无症状感染占病例的81.3%，而有症状感染占18.7%。恶性疟原虫与有症状病例相关，而非恶性疟原虫种类与无症状感染相关。研究结果表明，弗朗斯维尔存在常年性疟疾传播，突出了疟原虫物种多样性在疾病严重程度和临床表现中的作用，包括加蓬人群中间日疟原虫感染的首次报告。
