Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Org Lett. 2021 Oct 1;23(19):7640-7644. doi: 10.1021/acs.orglett.1c02862. Epub 2021 Sep 22.
Few xanthene-based near-infrared (NIR) photoacoustic (PA) dyes with absorbance >800 nm exist. As accessibility to these dyes requires long and tedious synthetic steps, we designed a NIR dye () with thienylpiperidine donors and a xanthene acceptor that is accessible in 3-4 synthetic steps. The dye boasts a strong PA signal at 880 nm with good biological compatibility and photostability, yields multiplexed imaging with an aza-BODIPY reference dye, and is detected at a depth of 4 cm.
目前仅有少数基于呫吨的近红外（NIR）光声（PA）染料具有 >800nm 的吸收。由于获得这些染料需要经过漫长而繁琐的合成步骤，我们设计了一种具有噻吩基哌啶给体和呫吨受体的 NIR 染料 ()，可以通过 3-4 步合成得到。该染料在 880nm 处具有较强的 PA 信号，具有良好的生物相容性和光稳定性，可与 aza-BODIPY 参考染料进行多重成像，并可在 4cm 深处检测到。
