Division of REI, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.
J Adolesc Young Adult Oncol. 2022 Aug;11(4):427-432. doi: 10.1089/jayao.2021.0115. Epub 2021 Sep 22.
Adolescents and young adults (AYAs) at risk of primary ovarian insufficiency (POI) often request fertility preservation consultation. We report consult/treatment outcomes for 21 cancer survivors and 3 mosaic Turner syndrome (TS) patients (mean age 21.6 at consult, 3 with POI). Ten AYAs (9 survivors, 1 mosaic TS) attempted ovarian stimulation; 4 cancelled for poor response. Of completed cycles, mean 3.8 mature oocytes were retrieved, with mean anti-Müllerian hormone 0.653 ng/mL. Ovarian stimulation for mosaic TS AYA and survivors is possible, even with diminished ovarian reserve. Further study is needed to establish guidelines for patient selection, treatment timing, and stimulation protocols.
有原发性卵巢功能不全（POI）风险的青少年和年轻成人（AYAs）通常会要求进行生育力保存咨询。我们报告了 21 例癌症幸存者和 3 例嵌合体特纳综合征（TS）患者（咨询时的平均年龄为 21.6 岁，3 例 POI）的咨询/治疗结果。10 名 AYA（9 例幸存者，1 例嵌合体 TS）尝试了卵巢刺激；4 例因反应不佳而取消。已完成的周期中，平均获得 3.8 个成熟卵母细胞，平均抗苗勒管激素为 0.653ng/ml。即使卵巢储备减少，嵌合体 TS AYA 和幸存者的卵巢刺激也是可能的。需要进一步的研究来制定患者选择、治疗时机和刺激方案的指南。
