Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Int J Cancer. 2022 Feb 1;150(3):509-520. doi: 10.1002/ijc.33816. Epub 2021 Oct 19.
Platelets promote tumor growth and metastasis in several tumor types. Recent research has found platelets can extravasate and infiltrate into the tumor stroma and interact with the tumor microenvironment. The prognostic role of platelet infiltration in colorectal cancer (CRC) remains controversial. A pan-cancer survival analysis was performed to find the potential prognostic value of platelet infiltration in patients with cancer. A survival analysis and a nomogram prognostic model were established to further confirm the results with data from our center. The correlations between patient outcomes and tumor-infiltrating platelets (TIPs) were identified by immunohistochemical staining for CD42b. The prognostic accuracy and discriminative ability of the nomogram were determined by the concordance index (C-index) and a calibration curve. The pan-cancer survival analysis showed platelet infiltration can lead to a poor prognosis in patients with several types of cancers, including CRC. Platelet infiltration was associated with overall survival (OS) and disease-free survival (DFS) in both primary and validation cohorts. The C-index values of the nomogram for predicting OS and DFS were 0.774 and 0.769, respectively, which were higher than that of the TNM staging system alone. Our study found platelet infiltration has a potential prognostic value regarding postsurgical survival in CRC patients. The proposed nomogram resulted in a more accurate prognostic prediction for postsurgical CRC patients.
血小板在多种肿瘤类型中促进肿瘤生长和转移。最近的研究发现，血小板可以渗出并浸润到肿瘤基质中，并与肿瘤微环境相互作用。血小板浸润在结直肠癌（CRC）中的预后作用仍存在争议。进行了泛癌生存分析，以寻找癌症患者血小板浸润的潜在预后价值。建立了生存分析和列线图预后模型，并用我们中心的数据进一步证实了结果。通过 CD42b 的免疫组织化学染色鉴定了患者结局与肿瘤浸润血小板（TIP）之间的相关性。通过一致性指数（C 指数）和校准曲线确定了列线图的预后准确性和判别能力。泛癌生存分析表明，血小板浸润可导致包括 CRC 在内的几种癌症患者预后不良。血小板浸润与原发性和验证队列中的总生存期（OS）和无病生存期（DFS）相关。预测 OS 和 DFS 的列线图的 C 指数值分别为 0.774 和 0.769，均高于单独的 TNM 分期系统。我们的研究发现，血小板浸润对 CRC 患者手术后的生存具有潜在的预后价值。提出的列线图可更准确地预测 CRC 患者手术后的预后。
