COVID-19 患者的临床特征、出院率和死亡率的荟萃分析。
COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.
机构信息
The First Clinical Medical School, Lanzhou University, Lanzhou, China.
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.
出版信息
J Med Virol. 2020 Jun;92(6):577-583. doi: 10.1002/jmv.25757. Epub 2020 Mar 23.
The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]).
本研究旨在分析 COVID-19 患者的临床数据、出院率和病死率，为临床提供帮助。从四个数据库中检索了 2019 年 12 月至 2020 年 2 月 COVID-19 患者的临床数据。我们对 COVID-19 患者的临床症状和实验室结果进行了统计学分析，并采用单臂荟萃分析解释了出院率和病死率。纳入了 10 篇文献中 1994 例患者的可用数据。COVID-19 患者的主要临床症状为发热（88.5%）、咳嗽（68.6%）、肌痛或乏力（35.8%）、咳痰（28.2%）和呼吸困难（21.9%）。次要症状包括头痛或头晕（12.1%）、腹泻（4.8%）、恶心和呕吐（3.9%）。实验室结果显示，淋巴细胞减少症（64.5%）、C 反应蛋白升高（44.3%）、乳酸脱氢酶升高（28.3%）和白细胞减少症（29.4%）更为常见。单臂荟萃分析结果显示，COVID-19 患者中男性占比较大，为 60%（95%CI[0.54,0.65]），COVID-19 患者的出院率为 52%（95%CI[0.34,0.70]），病死率为 5%（95%CI[0.01,0.11]）。
Zotero 插件