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COVID-19 患者的临床特征、出院率和死亡率的荟萃分析。

COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.

机构信息

The First Clinical Medical School, Lanzhou University, Lanzhou, China.

Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.

出版信息

J Med Virol. 2020 Jun;92(6):577-583. doi: 10.1002/jmv.25757. Epub 2020 Mar 23.

Abstract

The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]).

摘要

本研究旨在分析 COVID-19 患者的临床数据、出院率和病死率,为临床提供帮助。从四个数据库中检索了 2019 年 12 月至 2020 年 2 月 COVID-19 患者的临床数据。我们对 COVID-19 患者的临床症状和实验室结果进行了统计学分析,并采用单臂荟萃分析解释了出院率和病死率。纳入了 10 篇文献中 1994 例患者的可用数据。COVID-19 患者的主要临床症状为发热(88.5%)、咳嗽(68.6%)、肌痛或乏力(35.8%)、咳痰(28.2%)和呼吸困难(21.9%)。次要症状包括头痛或头晕(12.1%)、腹泻(4.8%)、恶心和呕吐(3.9%)。实验室结果显示,淋巴细胞减少症(64.5%)、C 反应蛋白升高(44.3%)、乳酸脱氢酶升高(28.3%)和白细胞减少症(29.4%)更为常见。单臂荟萃分析结果显示,COVID-19 患者中男性占比较大,为 60%(95%CI[0.54,0.65]),COVID-19 患者的出院率为 52%(95%CI[0.34,0.70]),病死率为 5%(95%CI[0.01,0.11])。

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