Levy R, Feustel P, Severinghaus J, Hosobuchi Y
Department of Neurosurgery, University of California, San Francisco 94143.
Bull Clin Neurosci. 1986;51:94-101.
The effect of the opiate antagonist naloxone on both the neurological deficit and regional cortical blood flow after middle cerebral artery occlusion in the cat was investigated. In animals with mild symptoms, naloxone did not consistently produce a significant behavioral effect. In all cats with neurological deficits, including hemiplegia or severe hemiparesis, 2 mg/kg naloxone administered intravenously 4 h after the ischemic lesion produced a reversal of neurological symptoms. This effect began within 2 min following naloxone injection and lasted for approximately 20 min. Animals were then anesthetized and cortical blood flow was measured by the hydrogen clearance method. Average cortical blood flow on the side of the occlusion was 50% that of the control side. Naloxone produced a significant additional decrease of 19.5% in cortical blood flow in the ischemic hemisphere, whereas no effect on blood flow on the control side was noted. Thus, although naloxone appears to temporarily reverse the severe neurological deficits resulting from middle cerebral artery occlusion in the cat, this effect appears to be accompanied by a decrease in local blood flow to the ischemic cortex.
研究了阿片拮抗剂纳洛酮对猫大脑中动脉闭塞后神经功能缺损和局部皮质血流的影响。在症状较轻的动物中，纳洛酮并未始终产生显著的行为效应。在所有出现神经功能缺损（包括偏瘫或严重半身轻瘫）的猫中，缺血性损伤4小时后静脉注射2mg/kg纳洛酮可使神经症状逆转。这种效应在注射纳洛酮后2分钟内开始，持续约20分钟。然后将动物麻醉，用氢清除法测量皮质血流。闭塞侧的平均皮质血流为对照侧的50%。纳洛酮使缺血半球的皮质血流显著额外降低了19.5%，而未观察到对对照侧血流有影响。因此，尽管纳洛酮似乎能暂时逆转猫大脑中动脉闭塞所致的严重神经功能缺损，但这种效应似乎伴随着缺血皮质局部血流的减少。
