Uemura Yoshiki, Komoto Marina, Okada Mitsuo
Department of Hematology, Chikamori Hospital, 1-1-16, Okawasuzi, Kochi-shi, Kochi- ken 780-8522, Japan.
Department of Cardiology, Chikamori Hospital, 1-1-16, Okawasuzi, Kochi-shi, Kochi- ken 780-8522, Japan.
Case Rep Hematol. 2021 Sep 11;2021:5237986. doi: 10.1155/2021/5237986. eCollection 2021.
A 71-year-old Japanese male was diagnosed with essential thrombocythemia (ET) with the JAK2 V617F mutation variation, in April 2011. He was mainly treated with hydroxyurea following which the number of platelets was maintained within the normal limit. At age 80, he was hospitalized due to cardiac tamponade. Computed tomography showed no evidence of tumor masses or lymphadenopathy. Pericardial drainage was performed, and cytopathologic examination of the fluid revealed atypical lymphoid cells consistent with an effusion lymphoma of B cell lineage. The pericardial effusion was completely drained, and complete remission was achieved. Ultimately, the patient was diagnosed with primary effusion lymphoma-like lymphoma (PEL-LL). To the best of our knowledge, this is the first report of PEL-LL following ET.
一名71岁的日本男性于2011年4月被诊断为伴有JAK2 V617F突变变异的原发性血小板增多症（ET）。他主要接受羟基脲治疗，之后血小板数量维持在正常范围内。80岁时，他因心脏压塞住院。计算机断层扫描未显示肿瘤肿块或淋巴结病的迹象。进行了心包引流，对液体的细胞病理学检查发现非典型淋巴细胞，与B细胞系渗出性淋巴瘤一致。心包积液完全引流，实现了完全缓解。最终，该患者被诊断为原发性渗出性淋巴瘤样淋巴瘤（PEL-LL）。据我们所知，这是ET后PEL-LL的首例报告。
