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基于伯基特膳食纤维假说的严重糖尿病胃轻瘫低成本新型治疗方法

A Low Cost, Novel Treatment of Severe Diabetic Gastroparesis Based on Burkitt's Dietary Fiber Hypothesis.

作者信息

Jones J Wesley, Lamont Katrina L, Stoltenberg Jennifer N, Brannan Grace D

机构信息

Department of Internal Medicine, Jerry M. Wallace School of Osteopathic Medicine, Campbell University, Buies Creek, USA.

Department of Internal Medicine, McLaren Macomb Hospital, Mt. Clemens, USA.

出版信息

Cureus. 2021 Sep 17;13(9):e18062. doi: 10.7759/cureus.18062. eCollection 2021 Sep.

DOI:10.7759/cureus.18062
PMID:34552840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8448520/
Abstract

We report a seven-year follow-up of a 43-year-old Hispanic female with severe diabetic gastroparesis (GP) and a 42.5 kg weight loss (45% of body mass), who required feeding jejunostomy tube placement. The patient had an excellent response to a treatment regime directed at increasing stool bulk, enhancing gut transit, and mobilizing intestinal gas by using dietary fiber supplements and osmotic laxatives with as needed tap water enemas. Hospital cost savings for this patient exceeded $125,000 annually. This case study suggests that constipation may substantially contribute to GP.

摘要

我们报告了一名43岁西班牙裔女性严重糖尿病性胃轻瘫(GP)患者的七年随访情况,该患者体重减轻42.5千克(占体重的45%),需要放置空肠造口喂养管。通过使用膳食纤维补充剂和渗透性泻药,并根据需要进行自来水灌肠,针对增加粪便体积、促进肠道蠕动和排出肠道气体的治疗方案,该患者反应良好。该患者每年节省的医院费用超过12.5万美元。本病例研究表明,便秘可能是导致胃轻瘫的重要因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba4/8448520/db3e68374973/cureus-0013-00000018062-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba4/8448520/db3e68374973/cureus-0013-00000018062-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba4/8448520/db3e68374973/cureus-0013-00000018062-i01.jpg

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引用本文的文献

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Comment on Suresh et al. The Short-Term Effects and Tolerability of Low-Viscosity Soluble Fibre on Gastroparesis Patients: A Pilot Clinical Intervention Study. 2021, , 4298.评 Suresh 等人的《低黏度可溶性纤维对胃轻瘫患者的短期疗效和耐受性:一项初步临床干预研究》。2021 年, ,4298 页。
Nutrients. 2022 Apr 28;14(9):1836. doi: 10.3390/nu14091836.
2
The Short-Term Effects and Tolerability of Low-Viscosity Soluble Fibre on Gastroparesis Patients: A Pilot Clinical Intervention Study.低黏度可溶性膳食纤维对胃轻瘫患者的短期疗效和耐受性:一项初步临床干预研究。
Nutrients. 2021 Nov 28;13(12):4298. doi: 10.3390/nu13124298.

本文引用的文献

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Constipation in Patients With Symptoms of Gastroparesis: Analysis of Symptoms and Gastrointestinal Transit.胃轻瘫症状患者的便秘:症状和胃肠传输分析。
Clin Gastroenterol Hepatol. 2022 Mar;20(3):546-558.e5. doi: 10.1016/j.cgh.2020.10.045. Epub 2020 Oct 28.
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Rheological Characteristics of Soluble Fibres during Chemically Simulated Digestion and their Suitability for Gastroparesis Patients.可溶性纤维在化学模拟消化过程中的流变特性及其对胃轻瘫患者的适用性。
Nutrients. 2020 Aug 17;12(8):2479. doi: 10.3390/nu12082479.
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Long-term Outcome of Gastric Per-Oral Endoscopic Pyloromyotomy in Treatment of Gastroparesis.
经口内镜下胃幽门肌切开术治疗胃轻瘫的长期疗效
Clin Gastroenterol Hepatol. 2021 Apr;19(4):816-824. doi: 10.1016/j.cgh.2020.05.039. Epub 2020 May 22.
4
The association between dietary fibre deficiency and high-income lifestyle-associated diseases: Burkitt's hypothesis revisited.膳食纤维缺乏与高收入生活方式相关疾病的关联:重新审视布氏假设。
Lancet Gastroenterol Hepatol. 2019 Dec;4(12):984-996. doi: 10.1016/S2468-1253(19)30257-2.
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Epidemiology and Diagnosis of Gastroparesis in the United States: A Population-based Study.美国胃轻瘫的流行病学和诊断:一项基于人群的研究。
J Clin Gastroenterol. 2020 Jan;54(1):50-54. doi: 10.1097/MCG.0000000000001231.
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Outcomes of per oral endoscopic pyloromyotomy in gastroparesis worldwide.全球范围内经口内镜下幽门肌切开术治疗胃轻瘫的结果。
World J Gastroenterol. 2019 Feb 28;25(8):909-922. doi: 10.3748/wjg.v25.i8.909.
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Is gastroparesis a gastric disease?胃轻瘫是一种胃部疾病吗?
Neurogastroenterol Motil. 2019 May;31(5):e13562. doi: 10.1111/nmo.13562. Epub 2019 Feb 17.
8
Gastroparesis: Medical and Therapeutic Advances.胃轻瘫:医学与治疗进展
Dig Dis Sci. 2017 Sep;62(9):2231-2240. doi: 10.1007/s10620-017-4679-7. Epub 2017 Jul 18.
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Healthcare utilization and costs associated with gastroparesis.与胃轻瘫相关的医疗保健利用情况和费用。
World J Gastroenterol. 2017 Jun 28;23(24):4428-4436. doi: 10.3748/wjg.v23.i24.4428.
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Electrical therapies for gastrointestinal motility disorders.用于胃肠动力障碍的电疗法。
Expert Rev Gastroenterol Hepatol. 2017 May;11(5):407-418. doi: 10.1080/17474124.2017.1298441. Epub 2017 Mar 21.