Wang Linlin, Li Ling, Zhu Guiquan
Department of Stomatology, Sichuan Cancer Hospital, Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Oncol. 2021 Sep 7;11:721785. doi: 10.3389/fonc.2021.721785. eCollection 2021.
Lymph node metastasis (LNM) of tumors is an established indicator of poor prognosis in patients. Tumor-associated lymphangiogenesis is a key step in LNM and has gained much attention. However, currently, there is no anti-tumor lymphangiogenesis drug used in clinical practice. Recently, studies on extracellular vesicles (EVs) have shown that different types of cells in the tumor microenvironment can release EVs that encapsulate a variety of molecules, including proteins, nucleic acids, and metabolites. Lymph endothelial cells (LECs) regulate tumor lymphangiogenesis through the uptake of EVs packed with different biologically active contents. In this review, we will discuss the possible mechanisms by which EVs participate in the regulation of tumor-associated lymphangiogenesis and LNM, summarize the potential value of EVs that can be used as biomarkers for the determination of tumor LNM, and indicate the potential anti-tumor lymphangiogenesis therapy.
肿瘤的淋巴结转移（LNM）是患者预后不良的既定指标。肿瘤相关的淋巴管生成是LNM的关键步骤，已受到广泛关注。然而，目前尚无用于临床实践的抗肿瘤淋巴管生成药物。最近，关于细胞外囊泡（EVs）的研究表明，肿瘤微环境中的不同类型细胞可以释放包裹多种分子的EVs，这些分子包括蛋白质、核酸和代谢产物。淋巴管内皮细胞（LECs）通过摄取含有不同生物活性成分的EVs来调节肿瘤淋巴管生成。在本综述中，我们将讨论EVs参与调节肿瘤相关淋巴管生成和LNM的可能机制，总结可作为确定肿瘤LNM生物标志物的EVs的潜在价值，并指出潜在的抗肿瘤淋巴管生成治疗方法。
