Department of Minimally Interventional Therapy, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, No. 519, Kunzhou Road, Xishan District, Kunming, 650118, Yunnan, China.
Department of Colorectal Surgery, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, No. 519, Kunzhou Road, Xishan District, Kunming, 650118, Yunnan, China.
J Physiol Biochem. 2022 Feb;78(1):99-108. doi: 10.1007/s13105-021-00843-8. Epub 2021 Sep 23.
The abnormal expression of transgelin-2 (TAGLN2) is related to tumor occurrence and progression. However, the underlying molecular mechanism of TAGLN2 in human colorectal cancer (CRC) is still poorly understood. Compared with adjacent tissues, TAGLN2 is overexpressed in CRC tissues. Its expression level is negatively correlated with the overall survival rate of patients with CRC. In addition, knockdown of TAGLN2 inhibited the proliferation and invasion of CRC cells. We also showed that TAGLN2 could interact with CD44 to regulate the Notch-1 signaling pathway. Our findings indicate there is increased TAGLN2 expression in CRC and that it may serve as a promising potential therapeutic target for CRC.
转谷氨酰胺酶 2（TAGLN2）的异常表达与肿瘤的发生和发展有关。然而，TAGLN2 在人结直肠癌（CRC）中的潜在分子机制仍知之甚少。与邻近组织相比，CRC 组织中 TAGLN2 过度表达。其表达水平与 CRC 患者的总生存率呈负相关。此外，TAGLN2 的敲低抑制了 CRC 细胞的增殖和侵袭。我们还表明，TAGLN2 可以与 CD44 相互作用，调节 Notch-1 信号通路。我们的研究结果表明 CRC 中 TAGLN2 的表达增加，它可能成为 CRC 有前途的潜在治疗靶点。
