Hsieh Tzu-Bou, Jin J-P
Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, United States.
Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, IL, United States.
Front Cell Dev Biol. 2023 Jun 8;11:1206147. doi: 10.3389/fcell.2023.1206147. eCollection 2023.
Calponin and transgelin (originally named SM22) are homologous cytoskeleton proteins that regulate actin-activated myosin motor functions in smooth muscle contraction and non-muscle cell motility during adhesion, migration, proliferation, phagocytosis, wound healing, and inflammatory responses. They are abundant cytoskeleton proteins present in multiple cell types whereas their physiological functions remain to be fully established. This focused review summarizes the evolution of genes encoding calponin and transgelin and their isoforms and discusses the structural similarity and divergence in vertebrate and invertebrate species in the context of functions in regulating cell motility. As the first literature review focusing on the evolution of the calponin-transgelin family of proteins in relevance to their structure-function relationship, the goal is to outline a foundation of current knowledge for continued investigations to understand the biological functions of calponin and transgelin in various cell types during physiological and pathological processes.
钙调蛋白和转胶蛋白（最初命名为SM22）是同源细胞骨架蛋白，在平滑肌收缩以及非肌肉细胞在黏附、迁移、增殖、吞噬作用、伤口愈合和炎症反应过程中的运动中，调节肌动蛋白激活的肌球蛋白运动功能。它们是存在于多种细胞类型中的丰富细胞骨架蛋白，但其生理功能仍有待充分明确。这篇重点综述总结了编码钙调蛋白和转胶蛋白及其亚型的基因的进化，并在调节细胞运动功能的背景下，讨论了脊椎动物和无脊椎动物物种中的结构相似性和差异。作为第一篇关注钙调蛋白 - 转胶蛋白家族蛋白质进化及其结构 - 功能关系的文献综述，其目的是概述当前知识基础，以便继续开展研究，了解钙调蛋白和转胶蛋白在生理和病理过程中在各种细胞类型中的生物学功能。
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