RASSF4信号在细胞命运中的“两面性”。
A "Janus" face of the RASSF4 signal in cell fate.
作者信息
Liu Aimei, Zhou Kaixiang, Martínez María Aránzazu, Lopez-Torres Bernardo, Martínez Marta, Martínez-Larrañaga María-Rosa, Wang Xu, Anadón Arturo, Ares Irma
机构信息
Department of National Reference, Laboratory of Veterinary Drug Residues (HZAU) and MOA Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China.
Department of MOA, Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Wuhan, Hubei, China.
出版信息
J Cell Physiol. 2022 Jan;237(1):466-479. doi: 10.1002/jcp.30592. Epub 2021 Sep 22.
RASSF4 (Ras-association domain family 4) is a protein-coding gene, regarded as a tumor suppressor regulated by DNA methylation. However, RASSF4 acts as a "Janus" in cell fate: death and survival. This review article focuses on the regulatory mechanisms of RASSF4 on cell death and cell survival and puts forward a comprehensive analysis of the relevant signaling pathways. The participation of RASSF4 in the regulation of intracellular store-operated Ca entry also affects cell survival. Moreover, the mechanism of inducing abnormal expression of RASSF4 was summarized. We highlight recent advances in our knowledge of RASSF4 function in the development of cancer and other clinical diseases, which may provide insight into the controversial functions of RASSF4 and its potential application in disease therapy.
RASSF4（Ras关联结构域家族4）是一个蛋白质编码基因，被视为受DNA甲基化调控的肿瘤抑制因子。然而，RASSF4在细胞命运（死亡与存活）方面扮演着“两面神”的角色。这篇综述文章聚焦于RASSF4对细胞死亡和细胞存活的调控机制，并对相关信号通路进行了全面分析。RASSF4参与细胞内储存-操作性钙内流的调控也会影响细胞存活。此外，还总结了诱导RASSF4异常表达的机制。我们着重介绍了RASSF4在癌症和其他临床疾病发生发展中的功能研究的最新进展，这可能有助于深入了解RASSF4具有争议性的功能及其在疾病治疗中的潜在应用。
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