Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Transpl Immunol. 2021 Dec;69:101472. doi: 10.1016/j.trim.2021.101472. Epub 2021 Sep 20.
The human leukocyte antigen (HLA) system plays an essential role in the peptides antigen presentation and more regulation of immune responses. Regarding all HLA molecules' associations with various diseases and their clinical utilities in understanding drug reactions or prediction of transplantation outcome, there is a need for much more extensive HLA data generated from Asian countries.
A comprehensive search was conducted in electronic databases between 1990 and 2021 to identify relevant articles to HLA frequency in the normal Iranian population. Two independent reviewers screened and selected the eligible studies. After data extraction, the meta-analysis was performed using STATA version 14. The overall frequencies and their 95% confidence intervals (CIs) were obtained using the random-effects model.
Among 1141 studies 78 were eligible for this study and the sample sizes varied from 14 to 15,600. The most frequent alleles of HLA class I were HLA-A02 (22%; 95%CI: 20-24%; I = 88.63%), -B35 (18%; 95%CI: 16-21%; I = 90.95%), -C12 (18%; 95%CI: 13-22%; I = 89.51%). HLA-DQA101 (42%; 95%CI: 40-44%; I = 56.80%), -DQB103 (38%; 95%CI: 35-42%; I = 92.38%), and -DRB111 (24%; 95%CI: 22-26%; I = 90.72%) were the most frequent alleles of HLA class II in Iran.
Our meta-analysis results point out that the comprehensive report of HLA allele frequency in the Iranian population could be helpful as reference data for planning and managing transplantation and immune disease treatment in Iran.
人类白细胞抗原（HLA）系统在肽抗原呈递和更广泛的免疫反应调节中起着至关重要的作用。鉴于所有 HLA 分子与各种疾病的关联及其在理解药物反应或预测移植结果方面的临床应用，亚洲国家需要生成更多广泛的 HLA 数据。
我们在电子数据库中进行了全面检索，检索时间从 1990 年到 2021 年，以鉴定与伊朗正常人群 HLA 频率相关的文章。两名独立的审查员筛选并选择了合格的研究。在提取数据后，我们使用 STATA 版本 14 进行了荟萃分析。使用随机效应模型获得总体频率及其 95%置信区间（CI）。
在 1141 项研究中，有 78 项符合纳入标准，样本量从 14 到 15600 不等。HLA Ⅰ类最常见的等位基因是 HLA-A02（22%；95%CI：20-24%；I=88.63%）、-B35（18%；95%CI：16-21%；I=90.95%）、-C12（18%；95%CI：13-22%；I=89.51%）。HLA-DQA101（42%；95%CI：40-44%；I=56.80%）、-DQB103（38%；95%CI：35-42%；I=92.38%）和-DRB111（24%；95%CI：22-26%；I=90.72%）是伊朗 HLA Ⅱ类最常见的等位基因。
我们的荟萃分析结果表明，全面报告伊朗人群 HLA 等位基因频率可以作为参考数据，有助于规划和管理伊朗的移植和免疫性疾病治疗。
