Gallagher J C, Goldgar D, Moy A
Creighton University School of Medicine, Omaha, NB.
J Bone Miner Res. 1987 Dec;2(6):491-6. doi: 10.1002/jbmr.5650020605.
Bone density in different regions of the skeleton was measured in 392 normal women aged 20-80 years by dual photon absorpiometry. In premenopausal women, aged 25-50 years, multiple regression analysis of regional bone density on age, height, and weight showed a small significant decrease in total bone density (less than 0.01) but no significant change in other regions of the skeleton. In postmenopausal women there were highly significant decreases in all regions of the skeleton (p less than 0.001), and bone density in these areas decreased as a logarithmic function of years since menopause. Based on multiple regression analyses, the decrease in spine density and total bone calcium was 2.5-3.0 times greater in the 25 years after menopause than the 25 years before menopause. The largest change, however, occurred in the first five years after menopause. During this time the estimated annual change in spine density and total bone calcium was about 10 times greater than that in the premenopausal period. These results demonstrate the important effect of the menopause in determining bone mass in later life.
采用双能光子吸收法对392名年龄在20至80岁的正常女性骨骼不同部位的骨密度进行了测量。在25至50岁的绝经前女性中，对各部位骨密度与年龄、身高和体重进行多元回归分析显示，总体骨密度有小幅显著下降（小于0.01），但骨骼其他部位无显著变化。在绝经后女性中，骨骼所有部位均有高度显著下降（p小于0.001），且这些部位的骨密度随绝经后的年数呈对数函数下降。基于多元回归分析，绝经后25年脊柱密度和总骨钙的下降幅度比绝经前25年大2.5至3.0倍。然而，最大的变化发生在绝经后的头五年。在此期间，脊柱密度和总骨钙的估计年变化量比绝经前时期大约大10倍。这些结果表明绝经对决定晚年骨量具有重要影响。
