Department of Neurology, Mayo Clinic, Rochester, Minnesota;
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
J Nucl Med. 2022 Jun;63(6):931-935. doi: 10.2967/jnumed.121.262685. Epub 2021 Sep 23.
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are 4-repeat (4R) tauopathies with overlapping, but also morphologically distinct, tau immunoreactive lesions that vary in count by brain region. F-flortaucipir PET uptake has been reported to correlate with overall tau burden, and-in 1 CBD case-to have greater affinity to threads than tangles. We determined whether F-flortaucipir uptake is associated with histologic lesion type in 4R tauopathies. We performed semiquantitative regional lesion counts on pretangles/neurofibrillary tangles, threads, oligodendroglial coiled bodies, tufted astrocytes, and astrocytic plaques in 29 cases of autopsied 4R tauopathy (PSP, 16; CBD, 13). Regression models were used for statistical analyses. F-flortaucipir uptake marginally correlated with threads in the precentral cortex ( = 0.04) and with astrocytic lesions in the red nucleus ( = 0.05). The findings do not support F-flortaucipir's having differential affinity to any 4R tau lesion type.
进行性核上性麻痹（PSP）和皮质基底节变性（CBD）是 4 重复（4R）tau 病，具有重叠但形态上不同的 tau 免疫反应性病变，其在脑区的数量不同。F-flortaucipir PET 摄取已被报道与总 tau 负担相关，并且在 1 例 CBD 病例中，与缠结相比，对线程具有更高的亲和力。我们确定 F-flortaucipir 摄取是否与 4R tau 病的组织学病变类型相关。我们对 29 例尸检 4R tau 病（PSP，16 例；CBD，13 例）的预缠结/神经原纤维缠结、线程、少突胶质线圈体、丛状星形胶质细胞和星形胶质细胞斑块进行了半定量区域性病变计数。使用回归模型进行统计分析。F-flortaucipir 摄取与中央前回中的线程（ = 0.04）和红核中的星形胶质细胞病变（ = 0.05）呈边缘相关性。这些发现不支持 F-flortaucipir 对任何 4R tau 病变类型具有不同的亲和力。
