Laboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
North Lab, 8-35 Kita, 2 Hondori, Shiroishi-ku, Sapporo, Hokkaido 003-0027, Japan.
J Vet Med Sci. 2021 Nov 24;83(11):1782-1785. doi: 10.1292/jvms.21-0206. Epub 2021 Sep 22.
The ideal treatment for intracranial histiocytic sarcoma (HS) remains unclear. Herein, we report a case of intracranial HS that was successfully treated using prednisolone and radiation therapy. The patient was a 9-year-old spayed female Pembroke Welsh Corgi that presented with epileptic seizures. Magnetic resonance imaging revealed a contrast-enhancing mass adjacent to the right piriform lobe. Prednisolone administration (1 mg/kg/day) decreased the lesion size. Additional palliative radiation therapy (total dose, 37 Gy) resulted in complete disappearance of the lesion. However, on day 164, the dog's neurological signs deteriorated, and she was euthanized. Necropsy revealed an intracranial metastasis of HS via the cerebrospinal fluid without any extracranial metastasis. Nonetheless, combined prednisolone and radiation therapy might be effective in treating intracranial HS.
颅内组织细胞肉瘤（HS）的理想治疗方法仍不清楚。在此，我们报告了一例成功用泼尼松龙和放射疗法治疗的颅内 HS 病例。该病例为一只 9 岁已绝育雌性彭布罗克威尔士柯基犬，表现为癫痫发作。磁共振成像显示右梨状叶附近有一个增强对比的肿块。泼尼松龙给药（1mg/kg/天）可使病变缩小。辅助姑息性放射治疗（总剂量 37Gy）可使病变完全消失。然而，在第 164 天，狗的神经症状恶化，被安乐死。尸检显示颅内 HS 通过脑脊液发生颅内转移，无任何颅外转移。尽管如此，联合泼尼松龙和放射疗法可能对治疗颅内 HS 有效。
