Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Japan.
Open Vet J. 2024 Oct;14(10):2700-2706. doi: 10.5455/OVJ.2024.v14.i10.20. Epub 2024 Oct 31.
Intracranial histiocytic sarcoma (HS) is uncommon in dogs, and no standard treatment has yet been defined for this disease. Herein, we describe a case of intracranial HS that responded favorably to nimustine treatment.
A 9-year-old, castrated Welsh Corgi Pembroke presented with a 2-month history of quadriplegia. Intracranial disease was suspected on neurological examination, and magnetic resonance imaging (MRI) revealed a contrast-enhanced mass in the left frontal lobe. Following tissue biopsy, the patient received intravenous nimustine (ACNU) treatment. The patient's neurological symptoms partially improved, and a reduction in tumor volume was observed on MRI on day 99. After three administrations of ACNU, tumor regrowth was confirmed on day 124, and temozolomide was subsequently administered. The patient subsequently showed no major changes in clinical symptoms, but subsequently died suddenly on day 195.
In this case, administration of ACNU provided temporary symptom improvement and tumor reduction. Therefore, ACNU monotherapy may be a therapeutic option for canine intracranial HS.
颅内组织细胞肉瘤（HS）在犬中较为罕见，目前尚未针对该疾病制定出标准的治疗方案。本文描述了一例对尼莫司汀治疗有良好反应的颅内 HS 病例。
一只 9 岁、已去势的威尔士柯基犬，表现出四肢瘫痪 2 个月的病史。神经学检查怀疑颅内疾病，磁共振成像（MRI）显示左额叶有一个增强对比的肿块。在进行组织活检后，该犬接受了静脉注射尼莫司汀（ACNU）治疗。患犬的神经症状部分改善，在第 99 天的 MRI 上观察到肿瘤体积缩小。在进行了三次 ACNU 治疗后，第 124 天确认肿瘤复发，并随后给予替莫唑胺治疗。此后，患犬的临床症状没有明显变化，但在第 195 天突然死亡。
在本病例中，ACNU 给药提供了暂时的症状改善和肿瘤缩小。因此，ACNU 单药治疗可能是犬颅内 HS 的一种治疗选择。
