Venniyoor Ajit, Al Farsi Abdul Aziz, Al Bahrani Bassim
Medical Oncology, National Oncology Center, The Royal Hospital, Muscat, OMN.
Oncology, National Oncology Center, The Royal Hospital, Muscat, OMN.
Cureus. 2021 Aug 20;13(8):e17320. doi: 10.7759/cureus.17320. eCollection 2021 Aug.
Non-alcoholic fatty liver disease (NAFLD) is a fast-spreading epidemic across the globe and has serious implications far beyond that of a "benign" liver condition. It is usually an outcome of ectopic fat storage due to chronic positive energy balance leading to obesity and is associated with multiple health problems. While association with cardiovascular disease and hepatocellular cancer is well recognized, it is becoming clear the NAFLD carries with it an increased risk of cancers of extrahepatic tissues. Studies have reported a higher risk for cancers of the colon, breast, prostate, lung, and pancreas. Fatty liver is associated with increased mortality; there is an urgent need to understand that fatty liver is not always benign, and not always associated with obesity. It is, however, a reversible condition and early recognition and intervention can alter its natural history and associated complications.
非酒精性脂肪性肝病（NAFLD）在全球范围内迅速蔓延，其影响远不止是一种“良性”肝脏疾病。它通常是由于慢性正能量平衡导致肥胖引起异位脂肪储存的结果，并与多种健康问题相关。虽然与心血管疾病和肝细胞癌的关联已得到充分认识，但越来越明显的是，NAFLD会增加肝外组织癌症的风险。研究报告称，患结肠癌、乳腺癌、前列腺癌、肺癌和胰腺癌的风险更高。脂肪肝与死亡率增加有关；迫切需要认识到，脂肪肝并不总是良性的，也不总是与肥胖相关。然而，它是一种可逆转的疾病，早期识别和干预可以改变其自然病程及相关并发症。
