Second Department of Surgery, University General Hospital of Alexandroupolis, Democritus University of Thrace Medical School, Dragana, 68100 Alexandroupolis, Greece.
Curr Oncol. 2022 Jun 25;29(7):4478-4510. doi: 10.3390/curroncol29070356.
Non-alcoholic fatty liver disease (NAFLD) is now considered the main driver and leading cause of chronic liver disease globally. The umbrella term NAFLD describes a range of liver conditions closely related to insulin resistance, metabolic syndrome, diabetes mellitus, obesity, and dyslipidemia. At the same time, several malignancies, including hepatocellular carcinoma and colorectal cancer, are considered to be common causes of death among patients with NAFLD. At first, our review herein aims to investigate the role of NAFLD in developing colorectal neoplasms and adenomatous polyps based on the current literature. We will also explore the connection and the missing links between NAFLD and extrahepatic cancers. Interestingly, any relationship between NAFLD and extrahepatic malignancies could be attributable to several shared metabolic risk factors. Overall, obesity, insulin resistance, metabolic syndrome, and related disorders may increase the risk of developing cancer. Therefore, early diagnosis of NAFLD is essential for preventing the progression of the disease and avoiding its severe complications. In addition, cancer screening and early detection in these patients may improve survival and reduce any delays in treatment.
非酒精性脂肪性肝病（NAFLD）现在被认为是全球慢性肝病的主要驱动因素和主要原因。NAFLD 这一总称描述了一系列与胰岛素抵抗、代谢综合征、糖尿病、肥胖和血脂异常密切相关的肝脏疾病。同时，几种恶性肿瘤，包括肝细胞癌和结直肠癌，被认为是 NAFLD 患者常见的死亡原因。首先，我们在此综述旨在根据现有文献研究 NAFLD 在发展结直肠肿瘤和腺瘤中的作用。我们还将探讨 NAFLD 与肝外癌症之间的联系和缺失环节。有趣的是，NAFLD 和肝外恶性肿瘤之间的任何关系都可能归因于一些共同的代谢危险因素。总的来说，肥胖、胰岛素抵抗、代谢综合征和相关疾病可能会增加患癌症的风险。因此，早期诊断 NAFLD 对于预防疾病进展和避免其严重并发症至关重要。此外，对这些患者进行癌症筛查和早期检测可能会提高生存率并减少治疗延误。
