Izadi Alireza, Soleimani Mohammad, Dos Santos Claudy Oliveira, Tehupeiory-Kooreman Marlou C, Daie Ghazvini Roshanak, Hashemi Seyed Jamal, Gramishoar Mohssen, Aminizadeh Mehdi, Abedinifar Zohre, Verweij Paul E, Khodavaisy Sadegh
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Ocular Trauma and Emergency, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Ophthalmic Inflamm Infect. 2021 Sep 24;11(1):30. doi: 10.1186/s12348-021-00255-1.
Pseudallescheria keratitis is rare but important type of fungal keratitis because of the inherently resistance of the organism to many existing antifungal agents.
Slit-lamp and confocal microscopy were used for clinical examinations. Fungal isolates were identified based on morphological characteristics and DNA sequence of the internal transcribed spacer region (ITS). In vitro antifungal susceptibility testing for fungal isolates was performed according to the Clinical and Laboratory Standards Institute (CLSI, M38-A2).
All patients had a history of ocular trauma. In clinical examination hypopion were seen in three patients. The main antifungal medications were topical voriconazole. After treatment the visual acuity of all patients improved in 2-3 weeks.
All four patients of Pseudallescheria keratitis had similar clinical features. Accurate and rapid identification of species should be helpful in treating p. boydii keratitis.
伪阿利什霉角膜炎是一种罕见但重要的真菌性角膜炎，因为该病原体对许多现有的抗真菌药物具有固有抗性。
使用裂隙灯和共聚焦显微镜进行临床检查。根据形态学特征和内转录间隔区（ITS）的DNA序列鉴定真菌分离株。根据临床和实验室标准协会（CLSI，M38-A2）对真菌分离株进行体外抗真菌药敏试验。
所有患者均有眼外伤史。临床检查中，3例患者可见前房积脓。主要的抗真菌药物是局部用伏立康唑。治疗后，所有患者的视力在2至3周内得到改善。
4例伪阿利什霉角膜炎患者具有相似的临床特征。准确快速地鉴定菌种有助于治疗博伊德氏假阿利什霉角膜炎。
