自闭症与脆性X综合征。
Autism and the fragile X syndrome.
作者信息
Fisch G S, Cohen I L, Wolf E G, Brown W T, Jenkins E C, Gross A
出版信息
Am J Psychiatry. 1986 Jan;143(1):71-3. doi: 10.1176/ajp.143.1.71.
The fragile X chromosome is an important factor in inherited mental retardation in males. It has also been reported that infantile autism is associated with fragile X. Recently, an article reported an examination of a small sample of autistic children in whom the fragile X chromosome was not found. Its authors concluded that if an association between fragile X and autism exists, it is infrequent. In the present study of 144 autistic male subjects, 18 were found to have the fragile X chromosome, supporting other (epidemiological) findings that the association between fragile X and autism occurs relatively frequently.
脆性X染色体是男性遗传性智力迟钝的一个重要因素。也有报道称，婴儿自闭症与脆性X有关。最近，一篇文章报道了对一小部分未发现脆性X染色体的自闭症儿童的检查。其作者得出结论，即使脆性X与自闭症之间存在关联，这种情况也不常见。在本项对144名自闭症男性受试者的研究中，发现有18人具有脆性X染色体，这支持了其他（流行病学）研究结果，即脆性X与自闭症之间的关联相对较为常见。
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