为什么自闭症与脆性X综合征有关联？概念和方法学问题。
Why are autism and the fragile-X syndrome associated? Conceptual and methodological issues.
作者信息
Cohen I L, Sudhalter V, Pfadt A, Jenkins E C, Brown W T, Vietze P M
机构信息
New York State Office of Mental Retardation and Developmental Disabilities, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.
出版信息
Am J Hum Genet. 1991 Feb;48(2):195-202.
Abstract
Investigations of the association between autism and the fragile-X syndrome have yielded conflicting results with some studies indicating a strong correlation and others indicating no relation between the disorders. In this paper, we review the relevant research on this controversy and discuss the conceptual and methodological problems involved in such an inquiry. We conclude that autism and fragile X are associated and that this relation will prove fruitful in understanding the role of the X chromosome in a variety of behavior disorders and in unraveling various theoretical accounts on the etiology of autism.
摘要
关于自闭症与脆性X综合征之间关联的调查结果相互矛盾，一些研究表明二者有很强的相关性，而另一些研究则表明这两种病症之间没有关联。在本文中，我们回顾了关于这一争议的相关研究，并讨论了此类探究中涉及的概念和方法问题。我们得出结论，自闭症与脆性X综合征有关联，并且这种关联将有助于理解X染色体在各种行为障碍中的作用，以及阐明关于自闭症病因的各种理论观点。
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