University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Compr Physiol. 2021 Sep 23;11(4):2467-2488. doi: 10.1002/cphy.c200036.
Hydrogen sulfide (H S) is a small, gaseous molecule with poor solubility in water that is generated by multiple pathways in many species including humans. It acts as a signaling molecule in many tissues with both beneficial and pathological effects. This article discusses its many actions in the vascular system and the growing evidence of its role to regulate vascular tone, angiogenesis, endothelial barrier function, redox, and inflammation. Alterations in some disease states are also discussed including potential roles in promoting tumor growth and contributions to the development of metabolic disease. © 2021 American Physiological Society. Compr Physiol 11:1-22, 2021.
硫化氢（H₂S）是一种小分子气体，在水中的溶解度较差，在包括人类在内的许多物种中通过多种途径产生。它作为一种信号分子在许多组织中发挥作用，具有有益和病理作用。本文讨论了它在血管系统中的多种作用，以及越来越多的证据表明它在调节血管张力、血管生成、内皮屏障功能、氧化还原和炎症方面的作用。还讨论了一些疾病状态下的变化，包括在促进肿瘤生长和代谢疾病发展方面的潜在作用。美国生理学会。《综合生理学》11:1-22,2021。
