Zuhra Karim, Tomé Catarina S, Forte Elena, Vicente João B, Giuffrè Alessandro
Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, I-00185 Rome, Italy; CNR Institute of Molecular Biology and Pathology, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
Instituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA), Avenida da República (EAN), 2780-157 Oeiras, Portugal.
Biochim Biophys Acta Bioenerg. 2021 Feb 1;1862(2):148338. doi: 10.1016/j.bbabio.2020.148338. Epub 2020 Nov 17.
Sulfane sulfur species comprise a variety of biologically relevant hydrogen sulfide (HS)-derived species, including per- and poly-sulfidated low molecular weight compounds and proteins. A growing body of evidence suggests that HS, currently recognized as a key signaling molecule in human physiology and pathophysiology, plays an important role in cancer biology by modulating cell bioenergetics and contributing to metabolic reprogramming. This is accomplished through functional modulation of target proteins via HS binding to heme iron centers or HS-mediated reversible per- or poly-sulfidation of specific cysteine residues. Since sulfane sulfur species are increasingly viewed not only as a major source of HS but also as key mediators of some of the biological effects commonly attributed to HS, the multifaceted role of these species in cancer biology is reviewed here with reference to HS, focusing on their metabolism, signaling function, impact on cell bioenergetics and anti-tumoral properties.
硫化氢类物质包括多种与生物学相关的硫化氢衍生物质，包括过硫化和多硫化的低分子量化合物及蛋白质。越来越多的证据表明，硫化氢目前被认为是人类生理和病理生理学中的关键信号分子，它通过调节细胞生物能量学和促进代谢重编程在癌症生物学中发挥重要作用。这是通过硫化氢与血红素铁中心结合或硫化氢介导的特定半胱氨酸残基的可逆过硫化或多硫化来实现对靶蛋白的功能调节。由于硫化氢类物质不仅越来越被视为硫化氢的主要来源，而且被视为一些通常归因于硫化氢的生物学效应的关键介质，因此本文参考硫化氢对这些物质在癌症生物学中的多方面作用进行综述，重点关注它们的代谢、信号功能、对细胞生物能量学的影响和抗肿瘤特性。
