普瑞巴林治疗肩关节镜手术的镇痛效果：一项随机对照试验的荟萃分析。

The analgesic efficacy of pregabalin for shoulder arthroscopy: A meta-analysis of randomized controlled trials.

机构信息

Department of Anesthesiology, People's Hospital of Chongqing Banan District.

Department of Hepatological Surgery, The People's Hospital of Kaizhou District, Chongqing, China.

出版信息

Medicine (Baltimore). 2021 Sep 24;100(38):e26695. doi: 10.1097/MD.0000000000026695.

DOI:10.1097/MD.0000000000026695

PMID:34559094

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8462647/

Abstract

INTRODUCTION: The efficacy of pregabalin for pain management of shoulder arthroscopy remains controversial. We conduct this meta-analysis to explore the influence of pregabalin versus placebo on the postoperative pain intensity of shoulder arthroscopy. METHODS: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through November 2019 for randomized controlled trials assessing the effect of pregabalin versus placebo on pain control of shoulder arthroscopy. This meta-analysis was performed using the random-effect model. RESULTS: Three randomized controlled trials were included in the meta-analysis. Overall, compared with control group for shoulder arthroscopy, pregabalin remarkably decreased pain scores at 0 to 1 hour (Std. MD = -0.57; 95% CI = -1.04 to -0.09; P = .02) and 12 hours (Std. MD = -0.37; 95% CI = -0.72 to -0.02; P = .04), as well as analgesic consumption (Std. MD = -1.84; 95% CI = -2.24 to -1.44; P < .00001), but showed no notable influence on pain scores at 24 hours (Std. MD = -0.54; 95% CI = -1.47 to 0.38; P = .25), nausea or vomiting (RR = 0.84; 95% CI = 0.53-1.33; P = .45), dizziness (RR = 1.14; 95% CI = 0.89-1.47; P = .30). CONCLUSIONS: Pregabalin may benefit to pain control after shoulder arthroscopy.

摘要

简介：普瑞巴林在肩关节镜手术疼痛管理中的疗效仍存在争议。我们进行这项荟萃分析旨在探讨普瑞巴林与安慰剂相比对肩关节镜术后疼痛强度的影响。

方法：我们通过检索 PubMed、EMbase、Web of Science、EBSCO 和 Cochrane 图书馆数据库，检索时间截至 2019 年 11 月，以评估普瑞巴林与安慰剂对肩关节镜手术疼痛控制效果的随机对照试验。这项荟萃分析采用随机效应模型进行。

结果：共有 3 项随机对照试验纳入荟萃分析。总体而言，与肩关节镜手术的对照组相比，普瑞巴林显著降低了术后 0 至 1 小时（标准均数差[Std. MD] = -0.57；95%置信区间[CI] = -1.04 至 -0.09；P =.02）和 12 小时（Std. MD = -0.37；95% CI = -0.72 至 -0.02；P =.04）的疼痛评分，以及镇痛药物的消耗量（Std. MD = -1.84；95% CI = -2.24 至 -1.44；P ＜.00001），但对术后 24 小时的疼痛评分（Std. MD = -0.54；95% CI = -1.47 至 0.38；P =.25）、恶心或呕吐（相对危险度[RR] = 0.84；95% CI = 0.53 至 1.33；P =.45）、头晕（RR = 1.14；95% CI = 0.89 至 1.47；P =.30）没有显著影响。

结论：普瑞巴林可能有益于肩关节镜术后的疼痛控制。