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酮咯酸补充对膝关节镜检查疼痛控制的影响：随机对照试验的荟萃分析。

Influence of Ketorolac Supplementation on Pain Control for Knee Arthroscopy: A Meta-Analysis of Randomized Controlled Trials.

机构信息

Department of Orthopaedic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Department of Orthopaedic Surgery, Chongqing Traditional Chinese Medical Hospital, Chongqing, China.

出版信息

Orthop Surg. 2020 Feb;12(1):31-37. doi: 10.1111/os.12608.

DOI:10.1111/os.12608
PMID:32077265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7031550/
Abstract

INTRODUCTION

The efficacy of ketorolac supplementation on pain control for knee arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the impact of ketorolac supplementation on pain intensity after knee arthroscopy.

METHODS

We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through September 2018 for randomized controlled trials (RCTs) assessing the effect of ketorolac supplementation vs placebo on pain management after knee arthroscopy. This meta-analysis is performed using the random-effect model.

RESULTS

Ten RCTs involving 402 patients are included in the meta-analysis. Overall, compared with control group for knee arthroscopy, ketorolac supplementation is associated with notably reduced pain scores at 1 h (MD = -0.66; 95% CI = -1.12 to -0.21; P = 0.004) and 2 h (MD = -0.90; 95% CI = -1.74 to -0.07; P = 0.03), prolonged time for first analgesic requirement (MD = 1.94; 95% CI = 0.33 to 3.55; P = 0.02) and decreased number of analgesic requirement (RR = 0.41; 95% CI = 0.23 to 0.75; P = 0.003), but has no obvious impact on analgesic consumption (MD = -0.56; 95% CI = -1.14 to 0.02; P = 0.06), as well as nausea and vomiting (RR = 0.44; 95% CI = 0.12 to 0.21; P = 0.21).

CONCLUSIONS

Ketorolac supplementation is effective to produce pain relief for knee arthroscopy.

摘要

简介

关于酮咯酸补充治疗对膝关节镜术后疼痛控制的疗效仍存在争议。我们进行了一项系统评价和荟萃分析，以探讨酮咯酸补充治疗对膝关节镜术后疼痛强度的影响。

方法

我们通过检索 PubMed、EMbase、Web of Science、EBSCO 和 Cochrane 图书馆数据库，收集了截至 2018 年 9 月评估膝关节镜术后酮咯酸补充治疗与安慰剂对照治疗疼痛管理效果的随机对照试验（RCT）。采用随机效应模型进行荟萃分析。

结果

共纳入 10 项 RCT 研究，涉及 402 例患者。总体而言，与膝关节镜术对照组相比，酮咯酸补充治疗可显著降低术后 1 小时（MD = -0.66；95%CI = -1.12 至 -0.21；P = 0.004）和 2 小时（MD = -0.90；95%CI = -1.74 至 -0.07；P = 0.03）的疼痛评分，首次需要镇痛药物的时间延长（MD = 1.94；95%CI = 0.33 至 3.55；P = 0.02）和镇痛药物需求次数减少（RR = 0.41；95%CI = 0.23 至 0.75；P = 0.003），但对镇痛药物消耗（MD = -0.56；95%CI = -1.14 至 0.02；P = 0.06）以及恶心呕吐（RR = 0.44；95%CI = 0.12 至 0.21；P = 0.21）无明显影响。

结论

酮咯酸补充治疗对膝关节镜术有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e318/7031550/b354c3e7230b/OS-12-31-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e318/7031550/b354c3e7230b/OS-12-31-g007.jpg
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本文引用的文献

1
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J Bone Joint Surg Am. 2018 Oct 3;100(19):1629-1636. doi: 10.2106/JBJS.18.00049.
2
Trends in the Use of Knee Arthroscopy in Adults.成年人膝关节镜使用趋势。
JAMA Intern Med. 2018 Nov 1;178(11):1557-1558. doi: 10.1001/jamainternmed.2018.4175.
3
Kinesiotaping Reduces Knee Diameter but Has No Effect on Differences Pain and Edema Following Knee Artroscopy.肌内效贴布可减小膝关节直径，但对膝关节镜检查后的疼痛和水肿差异无影响。
Acta Chir Orthop Traumatol Cech. 2018;85(4):285-290.
4
Randomized controlled trial of intra-articular ketorolac on pain and inflammation after minor arthroscopic knee surgery.随机对照试验：关节内注射酮咯酸对膝关节镜检查术后轻至中度疼痛和炎症的影响。
Acta Anaesthesiol Scand. 2018 Jul;62(6):829-838. doi: 10.1111/aas.13104. Epub 2018 Mar 7.
5
Prevalence and Predictive Factors of Chronic Postsurgical Pain and Global Surgical Recovery 1 Year After Outpatient Knee Arthroscopy: A Prospective Cohort Study.门诊膝关节镜检查术后1年慢性术后疼痛及整体手术恢复的患病率和预测因素：一项前瞻性队列研究
Medicine (Baltimore). 2015 Nov;94(45):e2017. doi: 10.1097/MD.0000000000002017.
6
Comparison of the effects of intra-articular sole ropivacaine and combined ketorolac and ropivacaine for pain control after knee arthroscopy surgery.关节腔内单独使用罗哌卡因与联合使用酮咯酸和罗哌卡因对膝关节镜手术后疼痛控制效果的比较。
Br J Pain. 2015 Aug;9(3):149-56. doi: 10.1177/2049463714553312.
7
A Single-Dose Intra-Articular Morphine plus Bupivacaine versus Morphine Alone following Knee Arthroscopy: A Systematic Review and Meta-Analysis.膝关节镜检查后单剂量关节内注射吗啡加布比卡因与单纯吗啡的比较：一项系统评价和荟萃分析。
PLoS One. 2015 Oct 16;10(10):e0140512. doi: 10.1371/journal.pone.0140512. eCollection 2015.
8
Arthroscopy for degenerative knee--a difficult habit to break?用于退行性膝关节的关节镜检查——一种难以改掉的习惯？
Acta Orthop. 2014 Jun;85(3):215-7. doi: 10.3109/17453674.2014.922736. Epub 2014 May 21.
9
Arthroscopy in the management of knee osteoarthritis.关节镜在膝关节骨关节炎治疗中的应用
Knee. 2014 Mar;21(2):351-2. doi: 10.1016/j.knee.2014.02.013.
10
Multimodal analgesia versus traditional opiate based analgesia after cardiac surgery, a randomized controlled trial.心脏手术后多模式镇痛与传统阿片类药物镇痛的随机对照试验
J Cardiothorac Surg. 2014 Mar 20;9:52. doi: 10.1186/1749-8090-9-52.