Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, P.R. China.
Medicine (Baltimore). 2021 Sep 24;100(38):e27305. doi: 10.1097/MD.0000000000027305.
This study aimed to retrospectively analyze risk factors for the prognosis of Chinese patients with endometrial carcinoma.Total 600 patients who were admitted to the Department of Gynecology, the Fourth Hospital of Hebei Medical University and were pathologically diagnosed as endometrial carcinoma after surgery from January 1, 1997 to December 31, 2006 were selected, and the related factors affecting their prognosis were analyzed.The survival of 600 patients with endometrial carcinoma was 2 to 136.5 months (average survival 57.39 ± 33.55 months), and 109 cases (18.2%) died from endometrial cancer. The overall survival rate of 1, 3, and 5 years after surgery was 96.8%, 89.9%, and 82.1%, respectively. Univariate analysis showed that age, menopausal status, pathological type, histological grade, pathological staging, tumor size, myometrial invasion, cervical involvement, ovarian metastasis, lymph node metastasis, and treatment method were the factors affecting the prognosis of endometrial carcinoma. Multivariate regression analysis showed that pathological type, histological grade, pathological staging, and cervical involvement were independent risk factors for the prognosis of endometrial carcinoma. The patients with high-grade and deep myometrial invasion, cervical involvement, full cavity tumor, and lymph node metastasis had a high incidence of ovarian metastasis.Pathological type, histological grade, pathological staging, and cervical involvement are independent risk factors affecting the prognosis of Chinese patients with endometrial carcinoma.
本研究旨在回顾性分析中国子宫内膜癌患者预后的危险因素。选取 1997 年 1 月 1 日至 2006 年 12 月 31 日在河北医科大学第四医院妇科住院并经手术病理证实为子宫内膜癌的 600 例患者，分析影响其预后的相关因素。600 例子宫内膜癌患者的生存时间为 2 至 136.5 个月（平均生存 57.39±33.55 个月），109 例（18.2%）死于子宫内膜癌。术后 1、3、5 年的总生存率分别为 96.8%、89.9%和 82.1%。单因素分析显示，年龄、绝经状态、病理类型、组织学分级、病理分期、肿瘤大小、肌层浸润、宫颈受累、卵巢转移、淋巴结转移和治疗方法是影响子宫内膜癌预后的因素。多因素回归分析显示，病理类型、组织学分级、病理分期和宫颈受累是影响子宫内膜癌预后的独立危险因素。高级别、深肌层浸润、宫颈受累、全腔肿瘤和淋巴结转移的患者卵巢转移发生率较高。病理类型、组织学分级、病理分期和宫颈受累是影响中国子宫内膜癌患者预后的独立危险因素。
