Vogel R I, Schneider L, Goteiner D
J Clin Periodontol. 1986 Feb;13(2):139-44. doi: 10.1111/j.1600-051x.1986.tb01447.x.
Prostaglandins are believed to be important mediators of periodontal inflammation and bone resorption. The purpose of the present blind study was to quantify clinically and histologically the effects of a topically applied nonsteroidal prostaglandin synthetase inhibitor, namely a substituted oxazolopyridine derivative (SOPD), on ligature-induced periodontal disease in the squirrel monkey. For a period of 14 days, one group of ligated animals received 2 daily topical applications of the SOPD. A group receiving systemically administered indomethacin served as a positive control while a group receiving only topically applied vehicle served as a negative control. Results indicate that throughout the 14-day period of the study, the SOPD significantly inhibited gingival inflammation and loss of attachment as compared to either the placebo or indomethacin groups. Both indomethacin and the SOPD significantly inhibited bone resorption.
前列腺素被认为是牙周炎症和骨吸收的重要介质。本双盲研究的目的是从临床和组织学角度量化局部应用非甾体类前列腺素合成酶抑制剂，即一种取代恶唑并吡啶衍生物（SOPD），对松鼠猴结扎诱导的牙周疾病的影响。在14天的时间里，一组结扎动物每天接受两次SOPD局部应用。接受全身给予吲哚美辛的一组作为阳性对照，而仅接受局部应用赋形剂的一组作为阴性对照。结果表明，在整个14天的研究期间，与安慰剂组或吲哚美辛组相比，SOPD显著抑制了牙龈炎症和附着丧失。吲哚美辛和SOPD均显著抑制了骨吸收。
