Gu Hua, Liu Weijian, Zhen Shijie, Long Saran, Sun Wen, Cao Jianfang, Zhao Xueze, Du Jianjun, Fan Jiangli, Peng Xiaojun
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.
Guangxi Key Laboratory of Electrochemical and Magneto-chemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541006, China.
ACS Appl Mater Interfaces. 2021 Oct 6;13(39):46353-46360. doi: 10.1021/acsami.1c14020. Epub 2021 Sep 24.
Rational manipulation of nonradiative decay channels is of crucial significance to improve photothermal conversion efficiency (PCE) and design photothermal agents. We first used the "internal and external combined" nonradiative decay strategy to enhance PCE. Specifically, organic IR-Y6 NPs with strong NIR absorption and high molar extinction coefficient were prepared and characterized. By means of TD-DFT calculations and fs-TA spectroscopy, the dual nonradiative decay channels composed of the free rotor (external strategy) and ultrafast dark excited states (DESs) between S and S states (internal strategy) were proved, which significantly enhanced PCE, up to 66%. IR-Y6 NPs were applied to a mice tumor model for photoacoustic image-guided photothermal therapy, showing complete tumor ablation ability and good biocompatibility for the normal organs. This work is of significance to deeply understand the nonradiation decay mechanism and rational design of high-performance PTT agents.
合理调控非辐射衰变通道对于提高光热转换效率（PCE）和设计光热剂至关重要。我们首先采用“内外结合”的非辐射衰变策略来提高PCE。具体而言，制备并表征了具有强近红外吸收和高摩尔消光系数的有机IR-Y6纳米颗粒。通过TD-DFT计算和飞秒瞬态吸收光谱，证明了由自由转子（外部策略）和S态与S态之间的超快暗激发态（DESs）组成的双重非辐射衰变通道，这显著提高了PCE，高达66%。IR-Y6纳米颗粒被应用于小鼠肿瘤模型进行光声图像引导的光热治疗，显示出完全的肿瘤消融能力以及对正常器官良好的生物相容性。这项工作对于深入理解非辐射衰变机制和合理设计高性能光热治疗剂具有重要意义。
