Gu Hua, Sun Wen, Du Jianjun, Fan Jiangli, Peng Xiaojun
State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials Dalian University of Technology Dalian China.
Ningbo Institute of Dalian University of Technology Ningbo China.
Smart Mol. 2023 Nov 23;2(2):e20230014. doi: 10.1002/smo.20230014. eCollection 2024 Jun.
The integration of robust photon-absorption capacity, high reactive oxygen species yields and photothermal conversion efficiency (PCE) into a single phototheranostic nano-agents is ideal but rarely reported. This study employed a dual-acceptor engineering strategy utilizing isoindigo and selenium-substituted [1,2,5]thiadiazolo[3,4-]pyridine to augment the molar extinction coefficient and spin-orbit coupling effect, respectively, resulting in a substantial enhancement of photon-absorption ability and non-radiative decay energy-release process of donor-acceptor type phototherapy molecules. As the optimal phototherapy agent, IID-PSe exhibited a high molar extinction coefficient two times that of photosensitizer, excellent O yield (15%) and PCE (34%), exhibiting great potential for phototherapy. After encapsulating with DSPE-PEG2000, IID-PSe NPs showed excellent anti-tumor phototherapy ability both in vitro and in vivo. This work provides an effective idea for designing high-performance photosensitive dyes with high efficiency phototherapy output.
将强大的光子吸收能力、高活性氧生成量和光热转换效率（PCE）整合到单一的光诊疗纳米剂中是理想的，但鲜有报道。本研究采用了一种双受体工程策略，利用异靛蓝和硒取代的[1,2,5]噻二唑并[3,4 - ]吡啶分别提高摩尔消光系数和自旋 - 轨道耦合效应，从而大幅增强供体 - 受体型光疗分子的光子吸收能力和非辐射衰变能量释放过程。作为最佳光疗剂，IID - PSe表现出比光敏剂高两倍的摩尔消光系数、优异的单线态氧生成量（15%）和PCE（34%），在光疗方面展现出巨大潜力。用DSPE - PEG2000包封后，IID - PSe纳米颗粒在体外和体内均表现出优异的抗肿瘤光疗能力。这项工作为设计具有高效光疗输出的高性能光敏染料提供了一个有效的思路。
