State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Org Lett. 2021 Oct 15;23(20):7900-7904. doi: 10.1021/acs.orglett.1c02908. Epub 2021 Sep 24.
A ligand-enabled nickel-catalyzed intramolecular hydroalkenylation of imines with unactivated alkenes has been developed. A variety of five- and six-membered cyclic allylic amines were synthesized in high yields. The use of both wide-bite-angle diphosphine ligand and Brønsted acid is crucial for realizing the reaction. Preliminary investigation of the asymmetric intramolecular hydroalkenylation of imines shows promising potential for the application of the method in the synthesis of enantio-enriched cyclic allylic amines.
一种配体辅助的镍催化的亚胺与非活化烯烃的分子内氢烯丙基化反应已经被开发出来。多种五元和六元环烯丙基胺以高产率合成。使用大位阻双膦配体和布朗斯特酸对于实现反应至关重要。初步研究表明，亚胺的不对称分子内氢烯丙基化反应具有潜在的应用前景，可用于合成对映体富集的环状烯丙基胺。
