双激光光动力疗法能有效消除口腔链球菌生物膜。
Dual-Light Photodynamic Therapy Effectively Eliminates Streptococcus Oralis Biofilms.
机构信息
Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland.
Department of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Finland and Department of Oral Medicine, Karolinska Institute, Huddinge, Sweden.
出版信息
J Pharm Pharm Sci. 2021;24:484-487. doi: 10.18433/jpps32084.
PURPOSE
During cancer treatment, oral mucositis due to radiotherapy or chemotherapy often leads to disruption of the oral mucosa, enabling microbes to invade bloodstream. Viridans streptococcal species are part of the healthy oral microbiota but can be frequently isolated from the blood of neutropenic patients. We have previously shown the antibacterial efficacy of dual-light, the combination of antibacterial blue light (aBL) and indocyanine green photodynamic therapy (aPDT).
METHODS
Here, we investigated the dual-light antibacterial action against four-day Streptococcus oralis biofilm. In addition, while keeping the total radiant exposure constant at 100J/cm2, we investigated the effect of changing the different relative light energies of aBL and aPDT to the antibacterial potential.
RESULTS
The dual-light had a significant antibacterial effect in all the tested combinations.
CONCLUSION
Dual-light can be used as an effective disinfectant against S. oralis biofilm.
目的
在癌症治疗过程中，放疗或化疗引起的口腔粘膜炎常导致口腔粘膜破裂，使微生物侵入血液。草绿色链球菌是健康口腔微生物群的一部分，但经常从中性粒细胞减少症患者的血液中分离出来。我们之前已经证明了双光（抗菌蓝光（aBL）和吲哚菁绿光动力疗法（aPDT）的组合）的抗菌功效。
方法
在这里，我们研究了双光对为期四天的口腔链球菌生物膜的抗菌作用。此外，在保持总辐照暴露量为 100J/cm2 不变的情况下，我们研究了改变 aBL 和 aPDT 的不同相对光能量对抗菌潜力的影响。
结果
双光在所有测试的组合中都具有显著的抗菌作用。
结论
双光可作为一种有效的消毒剂，用于治疗 S. oralis 生物膜。
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