Hurst L C, Badalamente M A, Makowski J
J Hand Surg Am. 1986 Jan;11(1):18-23. doi: 10.1016/s0363-5023(86)80093-4.
The in vitro response of myofibroblasts to prostaglandins F2alpha (a vasoconstrictor) and E2 (a vasodilator) were evaluated in specimens obtained from the Dupuytren's nodules of 12 patients. Fibroblasts from four control samples of palmar fascia were similarly tested. This study demonstrated the ability of prostaglandin F2alpha to induce significant contraction of myofibroblasts. Prostaglandin E2 was noted to cause significant relaxation of myofibroblasts. The contractile/relaxation responses of control fibroblasts to these prostaglandins were minimal.
在取自12例患者掌腱膜结节的标本中，评估了肌成纤维细胞对前列腺素F2α（一种血管收缩剂）和E2（一种血管扩张剂）的体外反应。对来自4个掌腱膜对照样本的成纤维细胞进行了类似测试。本研究证明了前列腺素F2α诱导肌成纤维细胞显著收缩的能力。注意到前列腺素E2可引起肌成纤维细胞显著松弛。对照成纤维细胞对这些前列腺素的收缩/松弛反应最小。
