Badalamente M A, Hurst L C, Sampson S P
Department of Orthopaedics, School of Medicine, State University of New York, Stony Brook 11794-8181.
J Hand Surg Am. 1988 Nov;13(6):867-71. doi: 10.1016/0363-5023(88)90261-4.
This study investigated if the vasoactive prostaglandins, PGE2, and PGF2 alpha, were identifiable in association with nodular myofibroblasts of patients with Dupuytren's disease. Immunocytochemic studies, using antibodies specific for these prostaglandins, have confirmed their association with myofibroblasts. Radioimmunoassay was used to quantitate the prostaglandins. Our results indicate a significant increase of both prostaglandins, especially PGF2 alpha, in Dupuytren's palmar fascia when compared with control fascia. These endogenous prostaglandins may influence the contractile behavior of myofibroblasts in Dupuytren's disease to contribute to the pathobiology of this disorder.
本研究调查了在杜普伊特伦挛缩症患者的结节性肌成纤维细胞中是否可识别出血管活性前列腺素PGE2和PGF2α。使用针对这些前列腺素的特异性抗体进行的免疫细胞化学研究证实了它们与肌成纤维细胞的关联。采用放射免疫测定法定量前列腺素。我们的结果表明，与对照筋膜相比，杜普伊特伦掌腱膜中这两种前列腺素，尤其是PGF2α，显著增加。这些内源性前列腺素可能会影响杜普伊特伦挛缩症中肌成纤维细胞的收缩行为，从而促成该疾病的病理生物学过程。
