膳食中单不饱和脂肪酸的摄入量与全因死亡率、心血管疾病和癌症风险的关系：一项前瞻性队列研究的系统评价和剂量反应荟萃分析。
Dietary intakes of monounsaturated fatty acids and risk of mortality from all causes, cardiovascular disease and cancer: A systematic review and dose-response meta-analysis of prospective cohort studies.
机构信息
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Ageing Res Rev. 2021 Dec;72:101467. doi: 10.1016/j.arr.2021.101467. Epub 2021 Sep 22.
BACKGROUND
Findings on the link between dietary intakes of monounsaturated fatty acids (MUFA) and risk of mortality are conflicting. This study aimed to summarize existing literature regarding the association between MUFA intake and risk of mortality from all causes, cardiovascular diseases (CVDs), and cancer.
METHODS
PubMed, Scopus, and ISI Web of Science was systematically searched up to December 2020. Prospective cohort studies which investigated MUFA intake in relation to mortality from all causes, CVD, or cancer were eligible for this systematic review. Publications that had reported risk ratios (RRs) or hazard ratios (HRs) and 95% confidence intervals (CIs) as effect size, were considered.
RESULTS
A total of 17 prospective cohort studies were included. These studies included 1022,321 participants aged ≥ 20 years in total, and 191,283 all-cause deaths, 55,437 CVD deaths, and 64,448 cancer deaths were totally reported. Combining 15 effect sizes from 11 studies, MUFA intake was inversely associated with risk of all-cause mortality (RR: 0.94; 95% CI: 0.90, 0.98; I =55.5; P = 0.005). Based on 17 effect sizes from 11 studies, we found no significant association between MUFA intake and risk of CVD mortality (RR: 0.95; 95% CI: 0.89, 1.01; I =37.0; P = 0.06). Combining 10 effect sizes from 6 studies, MUFA intake was not significantly associated with cancer mortality (RR: 0.99; 95% CI: 0.96, 1.03, I =13.3%, P = 0.32). Also, an additional 5% of energy from MUFA was associated with a 3% reduced risk of all-cause mortality (RR: 0.97; 95%CI: 0.96, 0.98), but not with CVD (RR: 0.98; 95%CI: 0.95, 1.01) and cancer mortality (RR: 0.99; 95%CI: 0.97, 1.01).
CONCLUSIONS
MUFA intake was found to be inversely associated with risk of all-cause mortality. However, no link was found between MUFA consumption and mortality from CVD or cancer.
背景
关于单不饱和脂肪酸（MUFA）的饮食摄入量与死亡率之间的联系的研究结果存在冲突。本研究旨在总结有关 MUFA 摄入量与全因死亡率、心血管疾病（CVD）和癌症死亡率之间关系的现有文献。
方法
系统检索了 PubMed、Scopus 和 ISI Web of Science 数据库，截至 2020 年 12 月。符合条件的研究为观察性队列研究，调查了 MUFA 摄入量与全因死亡率、CVD 或癌症死亡率之间的关系。将报告风险比（RR）或危害比（HR）和 95%置信区间（CI）作为效应量的出版物纳入本系统评价。
结果
共纳入 17 项前瞻性队列研究。这些研究共纳入了 1022321 名年龄≥20 岁的参与者，总共报告了 191283 例全因死亡、55437 例 CVD 死亡和 64448 例癌症死亡。综合 11 项研究中的 15 个效应量，MUFA 摄入量与全因死亡率降低相关（RR：0.94；95%CI：0.90，0.98；I =55.5；P=0.005）。基于 11 项研究中的 17 个效应量，我们发现 MUFA 摄入量与 CVD 死亡率之间无显著关联（RR：0.95；95%CI：0.89，1.01；I =37.0；P=0.06）。综合 6 项研究中的 10 个效应量，MUFA 摄入量与癌症死亡率无显著关联（RR：0.99；95%CI：0.96，1.03，I =13.3%，P=0.32）。此外，MUFA 额外增加 5%的能量摄入与全因死亡率降低 3%相关（RR：0.97；95%CI：0.96，0.98），但与 CVD（RR：0.98；95%CI：0.95，1.01）和癌症死亡率（RR：0.99；95%CI：0.97，1.01）无关。
结论
MUFA 摄入量与全因死亡率降低呈负相关。然而，MUFA 摄入量与 CVD 或癌症死亡率之间没有联系。
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