用于肺部感染的干粉制剂：载有环丙沙星的壳聚糖亚微米颗粒通过电喷雾生成。
Dry powder formulation for pulmonary infections: Ciprofloxacin loaded in chitosan sub-micron particles generated by electrospray.
机构信息
Institute of Nanoscience and Materials of Aragon (INMA) CSIC-Universidad de Zaragoza, Department of Chemical and Environmental Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/ Mariano Esquillor S/N, 50018 Zaragoza, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 28029 Madrid, Spain.
Institute of Nanoscience and Materials of Aragon (INMA) CSIC-Universidad de Zaragoza, Department of Chemical and Environmental Engineering, University of Zaragoza, Campus Río Ebro-Edificio I+D, C/ Mariano Esquillor S/N, 50018 Zaragoza, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, 28029 Madrid, Spain.
出版信息
Carbohydr Polym. 2021 Dec 1;273:118543. doi: 10.1016/j.carbpol.2021.118543. Epub 2021 Aug 8.
Electrospray was used as a one-step technique to generate inhalable ciprofloxacin-loaded chitosan sub-micron particles with potential use in the treatment of pulmonary infections. The effect of operating parameters was studied and the preparation method optimized. The final sizes of ciprofloxacin-loaded particles were 386.1 ± 248.5 nm and 501.1 ± 276.3 nm for high and low molecular weight chitosan, respectively. The high surface charge of the particles formed, around +45 mV, enhances their mucoadhesive properties. The particles were biocompatible with alveolar cell line (A549), and showed a high antimicrobial activity against two of the most common respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa.
电喷雾被用作一步法技术，以生成可吸入的载有环丙沙星的壳聚糖亚微米颗粒，可潜在用于治疗肺部感染。研究了操作参数的影响，并对制备方法进行了优化。对于高和低分子量壳聚糖，载有环丙沙星的颗粒的最终粒径分别为 386.1±248.5nm 和 501.1±276.3nm。颗粒形成的高表面电荷约为+45mV，增强了它们的黏膜黏附特性。这些颗粒与肺泡细胞系（A549）具有生物相容性，并对两种最常见的呼吸道病原体金黄色葡萄球菌和铜绿假单胞菌表现出很高的抗菌活性。
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