Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.
Department of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
J Gastrointest Cancer. 2022 Dec;53(4):939-947. doi: 10.1007/s12029-021-00715-w. Epub 2021 Sep 24.
This study was done to assess the effect of sarcopenia and other risk factors on the postoperative morbidity and perioperative mortality of patients undergoing elective surgery for gastric cancer.
This was a prospective cohort study comprising a single group of patients undergoing elective surgery for gastric cancer carried out in a tertiary care center in India. Patients diagnosed with gastric cancer underwent contrast-enhanced computed tomography preoperatively. Patients were considered sarcopenic when their skeletal muscle index (SMI) was < 34.9 cm/m for women and < 40.8 cm/m for men. Patients were planned for surgery ranging from gastrectomy with curative intent to palliative gastrojejunostomy. Postoperative complications including mortality were noted for 30 days following surgery and graded according to the Clavien-Dindo classification. The role of sarcopenia and other risk factors on the postoperative outcome of patients was noted.
A total of 100 patients were included in the study. There was a high prevalence of sarcopenia (62%) among patients with gastric cancer who underwent elective surgery. However, sarcopenia was not associated with any postoperative complication (p > 0.05) including 30-day mortality (p = 0.155), prolonged postoperative hospital stay (p = 0.876), or 30-day readmission rate (0.524). Among the variables considered, only esophagojejunostomy (p < 0.001) was associated with a poor postoperative outcome.
The present study showed that there was a high prevalence of sarcopenia (62%) in patients undergoing elective surgery for gastric cancer. However, it did not adversely affect the postoperative outcome. Among the variables considered, esophagojejunostomy alone was associated with a poor postoperative outcome.
本研究旨在评估肌肉减少症和其他危险因素对接受择期胃癌手术患者术后发病率和围手术期死亡率的影响。
这是一项在印度一家三级护理中心进行的、针对接受择期胃癌手术的单一患者组的前瞻性队列研究。患者在术前接受增强计算机断层扫描。当女性的骨骼肌指数（SMI）<34.9cm/m且男性的 SMI<40.8cm/m 时，患者被认为患有肌肉减少症。患者计划接受手术治疗，范围从根治性胃切除术到姑息性胃空肠吻合术。术后并发症（包括死亡率）在手术后 30 天内记录，并根据 Clavien-Dindo 分类进行分级。注意肌肉减少症和其他危险因素对患者术后结果的影响。
共有 100 例患者纳入本研究。接受择期胃癌手术的患者中肌肉减少症的患病率很高（62%）。然而，肌肉减少症与任何术后并发症（p>0.05）均无关，包括 30 天死亡率（p=0.155）、术后住院时间延长（p=0.876）或 30 天再入院率（0.524）。在所考虑的变量中，只有食管空肠吻合术（p<0.001）与不良的术后结果相关。
本研究表明，接受择期胃癌手术的患者中肌肉减少症的患病率很高（62%）。然而，它并没有对术后结果产生不利影响。在所考虑的变量中，只有食管空肠吻合术与不良的术后结果相关。
