Regional Cancer Centre, Trivandrum, India.
Regional Cancer Centre, Trivandrum, India.
Cancer Treat Res Commun. 2024;40:100829. doi: 10.1016/j.ctarc.2024.100829. Epub 2024 Jul 6.
Sarcopenia, defined as progressive and generalised loss of skeletal muscle mass, quality, and strength, is considered as a poor prognostic factor in cancer. Outcomes in oncology mainly focus on survival related to disease and treatment. Other factors affecting the end result get less attention. This study was conducted with the aim to determine presence of sarcopenia in operable gastric cancer, factors positively correlating with presence of sarcopenia and its impact on early postoperative outcomes.
This is a prospective study conducted from January 2020 to December 2021 in a tertiary care cancer hospital. All patients with adenocarcinoma stomach planned for curative intent surgery were assessed for sarcopenia by measuring hand grip strength(HGS) and skeletal muscle index(SMI). Comparison was made between patient and tumour related factors in patients with and without sarcopenia and impact of sarcopenia on early postoperative outcome was assessed.
74 patients were assessed for sarcopenia. 32 (43.2 %) were patients diagnosed with sarcopenia. Advanced age(p = 0.040), low BMI (p < 0.001), gastric outlet obstruction (p = 0.020) and urgent surgery (p = 0.002) positively correlated with sarcopenia. Curative resection was done in 68(91.89 %) patients and these patients were evaluated for early postoperative outcomes. 18 (26.5 %) patients had complications of Clavien Dindo grade 3 or above. Sarcopenia was not significantly associated with major postoperative complications(p = 0.857).
Sarcopenia, though associated with a substantial proportion of patients with gastric cancer, does not significantly affect early postoperative complications in a high volume oncology centre .
肌少症是一种进行性、全身性骨骼肌质量、力量和功能丧失的疾病，被认为是癌症不良预后的一个因素。肿瘤学的研究结果主要集中在与疾病和治疗相关的生存方面。其他影响最终结果的因素则较少受到关注。本研究旨在确定可手术胃癌患者中肌少症的存在，以及与肌少症存在相关的因素及其对术后早期结果的影响。
这是一项在一家三级癌症治疗医院进行的前瞻性研究，时间为 2020 年 1 月至 2021 年 12 月。所有计划进行根治性手术的胃腺癌患者均通过测量握力（HGS）和骨骼肌指数（SMI）来评估肌少症。比较了肌少症患者和非肌少症患者的患者和肿瘤相关因素，并评估了肌少症对术后早期结果的影响。
共对 74 例患者进行了肌少症评估，其中 32 例（43.2%）患者被诊断为肌少症。高龄（p = 0.040）、低 BMI（p < 0.001）、幽门梗阻（p = 0.020）和紧急手术（p = 0.002）与肌少症呈正相关。68 例（91.89%）患者接受了根治性切除术，并对其术后早期结果进行了评估。18 例（26.5%）患者发生了 Clavien Dindo 分级 3 级或以上的并发症。肌少症与主要术后并发症无显著相关性（p = 0.857）。
在高容量肿瘤中心，尽管肌少症与相当一部分胃癌患者相关，但它并不会显著影响术后早期并发症。
