甘油三酯/葡萄糖指数（TyG 指数）作为印度尼西亚雅加达育龄妇女血糖状态转换的标志物：茂物队列研究（2011-2016 年）。

Triglyceride/Glucose Index (TyG Index) as a marker of glucose status conversion among reproductive-aged women in Jakarta, Indonesia: The Bogor cohort study (2011-2016).

机构信息

Department of Public Health and Community Medicine, University of Sriwijaya, Indonesia; Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok Indonesia.

Department of Epidemiology, Public Health Faculty, Universitas Indonesia, Depok Indonesia.

出版信息

Diabetes Metab Syndr. 2021 Nov-Dec;15(6):102280. doi: 10.1016/j.dsx.2021.102280. Epub 2021 Sep 11.

DOI:10.1016/j.dsx.2021.102280

PMID:34562866

Abstract

BACKGROUND AND AIMS

Reproductive-aged women are prone to type 2 diabetes mellitus. This study aims to evaluate the optimal cut off point of Triglyceride/Glucose Index for predicting glucose status conversion among women of reproductive age.

METHODS

This study involved normoglycemic and prediabetes women aged 20-49 years from the Bogor Non-Communicable Diseases Cohort Study (West Java, Indonesia) conducted from 2011 to 2016. Statistical analysis was performed using Receiver Operating Characteristics curve analysis with STATA version 15.

RESULTS

Among prediabetes subjects (n = 371), the cut-off point of TyG index for regression from prediabetes to normoglycemic subjects was <4.51 [sensitivity, specificity, AUC (95%CI) 83.9%, 80.1%, 0.913 (0.875-0.943), respectively] and the cut-off point for progression from prediabetes to diabetes was >4.54 [80.0%, 73.1%, 0.858 (0.807-0.900)]. Among normoglycemic subjects (n = 1300), the cut-off point of TyG index for progression to prediabetes and diabetes were >4.44 [80.1%, 71.1%, 0.834 (0.812-0.854)] and >4.47 [80.6%, 80.8%, 0.909 (0.890-0.926)] respectively.

CONCLUSION

Based on sample of subjects evaluated between 2011 and 2016, TyG index appears to be a promising marker for glucose status conversion among reproductive-aged women in Jakarta, Indonesia.

摘要

背景和目的

育龄期女性易患 2 型糖尿病。本研究旨在评估甘油三酯/葡萄糖指数的最佳截断值，以预测育龄期女性的血糖状态转换。

方法

本研究纳入了 2011 年至 2016 年在西爪哇省茂物非传染性疾病队列研究（印度尼西亚雅加达）中年龄在 20-49 岁的血糖正常和糖尿病前期女性。使用 STATA 版本 15 进行统计分析，采用接受者操作特征曲线分析。

结果

在糖尿病前期患者（n=371）中，TyG 指数从糖尿病前期回归至血糖正常的截断点为<4.51 [敏感度、特异度、AUC（95%CI）分别为 83.9%、80.1%、0.913（0.875-0.943）]，从糖尿病前期进展至糖尿病的截断点为>4.54 [80.0%、73.1%、0.858（0.807-0.900）]。在血糖正常的患者（n=1300）中，TyG 指数进展至糖尿病前期和糖尿病的截断点分别为>4.44 [80.1%、71.1%、0.834（0.812-0.854）]和>4.47 [80.6%、80.8%、0.909（0.890-0.926）]。