Department of Rehabilitation, Shenzhen Dapeng New District Nan'ao People's Hospital, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Front Endocrinol (Lausanne). 2024 Sep 23;15:1416634. doi: 10.3389/fendo.2024.1416634. eCollection 2024.
The triglyceride-glucose (TyG) index, recognized for its cost-efficiency and simplicity, serves as an accessible indicator of insulin resistance. Yet, its correlation with the risk of prediabetes and diabetes (Pre-DM/DM) in the Chinese demographic remains uncertain. Consequently, our study explored the association between the TyG index and the development of Pre-DM/DM within the Chinese population.
The retrospective cohort study was carried out utilizing data from a health screening initiative. The study included 179541 adults over 20 who underwent medical examinations at the Rich Healthcare Group over a period spanning from 2010 to 2016. The correlation between the TyG index and Pre-DM/DM risk was investigated using Cox regression analysis. Furthermore, Cox proportional hazards regression with cubic spline functions and smooth curve fitting was incorporated to explore their non-linear connection.
The mean age of study participants was 41.18 ± 12.20 years old, and 95255 (53.05%) were male. During a median follow-up of 3.01 years, 21281 (11.85%) participants were diagnosed with Pre-DM/DM. After adjusting the potential confounding factors, the results showed that the TyG index was positively correlated with incident Pre-DM/DM (HR: 1.67, 95%CI: 1.62-1.71, P< 0.001). Additionally, a non-linear association was observed between the TyG index and the onset of Pre-DM/DM, with an inflection point identified at 8.73. Hazard ratios (HR) to the left and right of this inflection point were 1.95 (95%CI: 1.86-2.04) and 1.34 (95%CI: 1.27-1.42), respectively. Furthermore, sensitivity analyses confirmed the stability of these findings.
The TyG index exhibited a non-linear positive relationship with the risk of Pre-DM/DM. These findings imply that maintaining the TyG index at a lower, specified threshold may be beneficial in mitigating the onset of Pre-DM/DM.
甘油三酯-葡萄糖（TyG）指数因其成本效益和简单性而被认可，可作为胰岛素抵抗的一个便捷指标。然而，它与中国人群中糖尿病前期和糖尿病（Pre-DM/DM）风险的相关性尚不确定。因此，我们的研究旨在探讨 TyG 指数与中国人群中 Pre-DM/DM 发病风险之间的关系。
本回顾性队列研究利用了 2010 年至 2016 年期间在瑞慈医疗集团接受体检的 179541 名 20 岁以上成年人的健康筛查数据。使用 Cox 回归分析探讨 TyG 指数与 Pre-DM/DM 风险的相关性。此外，采用 Cox 比例风险回归和三次样条函数及平滑曲线拟合来探讨它们之间的非线性关系。
研究参与者的平均年龄为 41.18 ± 12.20 岁，其中 95255 人（53.05%）为男性。在中位随访 3.01 年后，21281 人（11.85%）被诊断为 Pre-DM/DM。在调整潜在混杂因素后，结果显示 TyG 指数与 Pre-DM/DM 发病风险呈正相关（HR：1.67，95%CI：1.62-1.71，P<0.001）。此外，TyG 指数与 Pre-DM/DM 的发病之间存在非线性关系，在 8.73 处存在拐点。拐点左侧和右侧的危险比（HR）分别为 1.95（95%CI：1.86-2.04）和 1.34（95%CI：1.27-1.42）。此外，敏感性分析证实了这些发现的稳定性。
TyG 指数与 Pre-DM/DM 的发病风险呈非线性正相关。这些发现表明，将 TyG 指数保持在较低的特定阈值可能有助于降低 Pre-DM/DM 的发病风险。
