Kessler Foundation, 120 Eagle Rock Ave, Suite 100, East Hanover, NJ 07936, USA; Children's Specialized Hospital Research Center, New Brunswick, NJ, USA; Departments of Physical Medicine and Rehabilitation; and Neurology, Rutgers, New Jersey Medical School, Newark, NJ, USA; Palestinian Neuroscience Initiative, Al-Quds University, Jerusalem, Palestine.
Kessler Foundation, 120 Eagle Rock Ave, Suite 100, East Hanover, NJ 07936, USA; Departments of Physical Medicine and Rehabilitation; and Neurology, Rutgers, New Jersey Medical School, Newark, NJ, USA.
Mult Scler Relat Disord. 2021 Nov;56:103273. doi: 10.1016/j.msard.2021.103273. Epub 2021 Sep 20.
Fatigue is the most common symptom in multiple sclerosis (MS), previously attributed to dopamine imbalance. Evidence suggests that methylphenidate, a psychostimulant that increases striatal and prefrontal dopamine levels, is effective in reducing fatigue in various disorders. However, its effect on state vs. trait mental fatigue in MS is yet to be examined.
This pilot study investigates the efficacy of methylphenidate on decreasing self-reported mental fatigue in 12 individuals with MS in a double-blind, placebo-controlled, cross-over randomized clinical trial.
Our results show that "state", but not "trait" MS-related fatigue, was reduced after 4 weeks of methylphenidate administration as compared to placebo.
疲劳是多发性硬化症（MS）最常见的症状，以前归因于多巴胺失衡。有证据表明，哌醋甲酯是一种能增加纹状体和前额叶多巴胺水平的精神兴奋剂，在各种疾病中能有效减轻疲劳。然而，它对 MS 中状态性与特质性精神疲劳的影响尚未被研究。
本研究采用双盲、安慰剂对照、交叉随机临床试验，研究了哌醋甲酯对 12 名 MS 患者自我报告的精神疲劳的影响。
我们的研究结果表明，与安慰剂相比，哌醋甲酯治疗 4 周后，仅“状态性”而非“特质性”的 MS 相关疲劳减轻。
