Elad David, Jaffa Ariel J, Grisaru Dan, Leibovitch Ilan
Department of Biomedical Engineering, Faculty of Engineering, Tel-Aviv University, Tel-Aviv 6997801, Israel.
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel-Aviv Medical Center, Tel-Aviv 6423906, Israel.
J Dev Biol. 2021 Aug 29;9(3):35. doi: 10.3390/jdb9030035.
It is well established that the intrauterine biological environment plays important roles in fetal development. In this review, we re-visit the hypothesis that testicular germ cell cancer (TGCC), especially in adolescents and young adults, has been programmed in utero. The origin for extreme in utero environments is mostly maternal driven and may be due to nutritional, physical and psychological stressful conditions that alter the optimal molecular and biophysical in utero environments. Moreover, precursors for TGCC may originate as early as during fertilization or implantation of the blastocyst. Further investigations of human developmental biology, both in vivo and in vitro, are needed in order to establish better understanding of in utero programming of future wellbeing or diseases.
众所周知，子宫内的生物环境在胎儿发育中起着重要作用。在本综述中，我们重新审视了这样一种假说，即睾丸生殖细胞癌（TGCC），尤其是在青少年和年轻成年人中，是在子宫内就已被编程的。子宫内极端环境的起源大多由母亲驱动，可能是由于营养、身体和心理压力状况改变了子宫内最佳的分子和生物物理环境。此外，TGCC的前体可能早在囊胚受精或着床时就已产生。为了更好地理解子宫内对未来健康或疾病的编程，需要对人类发育生物学进行更多的体内和体外研究。
