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使用不同光束传输技术的 ArF 准分子激光角膜屈光手术中温度分布的计算研究。

Computational study for temperature distribution in ArF excimer laser corneal refractive surgeries using different beam delivery techniques.

机构信息

Department of Mathematics, School of Science, Kathmandu University, Dhulikhel, Nepal.

Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

出版信息

Lasers Med Sci. 2022 Apr;37(3):1709-1716. doi: 10.1007/s10103-021-03420-z. Epub 2021 Sep 26.

DOI:10.1007/s10103-021-03420-z
PMID:34564765
Abstract

Refractive errors are the most common causes of vision impairment worldwide and laser refractive surgery is one of the most frequently performed ocular surgeries. Clinical studies have reported that approximately 10.5% of patients need an additional procedure after the surgery. The major complications of laser surgery are over/under correction and dry eye. An increase in temperature may be a cause for these complications. The purpose of this study was to estimate the increase in temperature during laser refractive surgery and its relationship with the complications observed for different surgical techniques. In this paper, a finite element model was applied to investigate the temperature distribution of the cornea when subjected to ArF excimer laser at a single spot using various beam delivery systems (broad beam, scanning slit, and flying spot). The Pennes bio-heat equation was used to predict the temperature values at different laser pulse energies and frequencies. The maximum temperature increase by ArF laser ([Formula: see text] frequency and [Formula: see text] pulse energy) at a single spot was [Formula: see text] for [Formula: see text] diopter correction ([Formula: see text] of ablation of corneal stroma) using broad beam, scanning slit, and flying spot beam delivery approaches respectively. The peak temperature due to a single pulse was estimated to be [Formula: see text]. Although the peak temperature (sufficient energy to break intermolecular bonds) exists for a very short time ([Formula: see text]) compared to the thermal relaxation time ([Formula: see text]), there is some thermal energy exchange between corneal tissues during a laser refractive surgery. Heating may cause collagen denaturation, collagen shrinkage, and more evaporation and hence proposed to be a risk factor for over/under correction and dry eye.

摘要

屈光不正(refractive errors)是全球视力损害的最常见原因,激光屈光手术(laser refractive surgery)是最常进行的眼部手术之一。临床研究报告称,手术后约有 10.5%的患者需要进行额外的手术。激光手术的主要并发症是矫正过度/不足(over/under correction)和干眼症(dry eye)。温度升高可能是这些并发症的原因之一。本研究旨在估计激光屈光手术期间的温度升高及其与不同手术技术观察到的并发症之间的关系。在本文中,应用有限元模型(finite element model)研究了角膜在使用不同光束传输系统(broad beam、扫描狭缝和飞点)对单个点的 ArF 准分子激光照射时的温度分布。彭内斯生物传热方程(Pennes bio-heat equation)用于预测不同激光脉冲能量和频率下的温度值。在单个点处,ArF 激光([Formula: see text] 频率和 [Formula: see text] 脉冲能量)引起的最大温升为 [Formula: see text],用于 [Formula: see text] 屈光度([Formula: see text] 的角膜基质消融),分别使用宽带、扫描狭缝和飞点光束传输方法。单脉冲引起的峰值温度估计为 [Formula: see text]。尽管与热弛豫时间(thermal relaxation time)相比,单个脉冲的峰值温度(足以打破分子间键的能量)仅存在很短的时间([Formula: see text]),但在激光屈光手术过程中,角膜组织之间存在一些热能交换。加热可能导致胶原变性、胶原收缩和更多的蒸发,因此被认为是矫正过度/不足和干眼症的危险因素。

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