Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China.
Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Sciences, 510650 Guangzhou, Guangdong, China.
Rev Cardiovasc Med. 2021 Sep 24;22(3):967-973. doi: 10.31083/j.rcm2203105.
The prognostic value of the sequential organ failure assessment (SOFA) score for critically ill elderly patients with acute infective endocarditis (IE) remains unknown. From January 2015 to December 2019, 111 elderly (≥65 years) patients with acute IE were consecutively included and divided into a low SOFA (<6) group (n = 71) and a high SOFA (≥6) group (n = 40). Endpoints included in-hospital and long-term (12-36 month) mortality. A high SOFA score was related to higher incidence of in-hospital mortality (30.0%) with an area under the curve (AUC) of 0.796. In multivariate analysis, age [odds ratio (OR) = 2.21, 95% confidence intervals (CI), 1.16-6.79, = 0.040], SOFA ≥6 (OR = 6.38, 95% CI, 1.80-16.89, = 0.004) and surgical treatment (OR = 0.21, 95% CI, 0.05-0.80, = 0.021) were predictive of in-hospital mortality. A Cox proportional-hazards model identified age [Hazard ratios (HR)= 2.85, 95% CI, 1.11-7.37, = 0.031], diabetes mellitus (HR = 3.99, 95% CI, 1.35-11.80, = 0.013), SOFA ≥6 (OR = 3.38, 95% CI, 1.26-9.08, = 0.001) and surgical treatment (HR = 0.24, 95% CI, 0.08-0.68, = 0.021) as predictors of long-term mortality. A high SOFA score predicts a poor outcome including in-hospital and long-term mortality in critically ill elderly patients with acute IE.
序贯器官衰竭评估（SOFA）评分对危重病老年急性感染性心内膜炎（IE）患者的预后价值尚不清楚。2015 年 1 月至 2019 年 12 月，连续纳入 111 例老年（≥65 岁）急性 IE 患者，分为低 SOFA（<6）组（n=71）和高 SOFA（≥6）组（n=40）。终点包括院内和长期（12-36 个月）死亡率。高 SOFA 评分与较高的院内死亡率相关（30.0%），曲线下面积（AUC）为 0.796。多因素分析显示，年龄[比值比（OR）=2.21，95%置信区间（CI），1.16-6.79，=0.040]、SOFA≥6（OR=6.38，95%CI，1.80-16.89，=0.004）和手术治疗（OR=0.21，95%CI，0.05-0.80，=0.021）是院内死亡的预测因素。Cox 比例风险模型确定年龄[危险比（HR）=2.85，95%CI，1.11-7.37，=0.031]、糖尿病（HR=3.99，95%CI，1.35-11.80，=0.013）、SOFA≥6（OR=3.38，95%CI，1.26-9.08，=0.001）和手术治疗（HR=0.24，95%CI，0.08-0.68，=0.021）是长期死亡的预测因素。高 SOFA 评分预测危重病老年急性 IE 患者预后不良，包括院内和长期死亡率。
